Wallace West has updated his costume in the final issue and is implied to taken on the mantle of the new Flash. Despair Event Horizon: Ever since Barda's infection, Mister Miracle has lived alone in a cabin in the middle of nowhere in a deep depression. It takes John Constantine promising him that there's a cure for the Anti-Life infection while holding the Lasso of Truth to get him out of it. After an infected Superman is surrounded by the Green Lantern Corps, he retreats into the Sun to drain it and kill the remaining humans on Earth. Erebos tries to negotiate with Damian but it doesn’t work. Jon Kent and Alfred Pennyworth sit by Damian so he doesn’t face the end alone. Jon then tells Damian he was a great Batman as the Life Equation and Anti-Life Equation collide to create a new Big Bang. Issue #3 reveals that Mister Miracle managed to escape the Anti-Life horde and has been living in seclusion all this time.

The above is also foreshadowed when Jason recognizes one of the imprisoned infected is Billy Batson. Dude, Not Funny!: In Issue #6, when the decision is made to evacuate what's left of humanity away from Sol, Guy Gardner jokes that this might look a little bad on the Corps, losing a sector and all. Dinah chews him out over it, but he justifies this by stating that he's scared right now and being his normal asshole self is the only way he can cope.Bash Brothers: Creeper and Solomon Grundy get along the best of all the villains assembled. They even hold arms right before they go and face the Infected Wonder Woman despite knowing it's suicidal. This miniseries explores what the villains were up to during the events of the original comic book series. My mother used to tell me there was no such thing as monsters. There was nothing hiding in the dark. Nothing was going to jump out of the shadows. I wish I could have told my child the same thing. But by the time I was grown, I'd seen too many monsters. I knew they were real. There was one thing I didn't know... Things go From Bad to Worse in the fifth issue with the deaths of Martian Manhunter, Lex Luthor, The Flash, and Superman.

Batman's plan for neutralizing Superman involved using kryptonite to synthesize gas that would slow him down. Wonder Woman explicitly notes that it (along with all of Batman's methods) wasn't intended to be lethal. Take a Third Option: The Anti-Life Equation takes this approach in the final climax when Infected!Superman faces off against the entire Green Lantern Corps. The Equation is compelled to spread death and destruction, but is intelligent enough to realise that even Infected!Superman cannot defeat them all together — and so instead of fighting them, he instead flies into Earth's sun and begins to drain it, thus ensuring that it will destroy the solar system much sooner and eventually kill off everyone remaining there.Ragtag Bunch of Misfits: A Good Day to Die focuses on a group of heroes consisting of Mr. Terrific, Big Barda, Mister Miracle, Blue Beetle, Booster Gold, and John Constantine. All but Constantine end up killed or infected.