If you're unsure whether this is the right part for your needs, we've got you covered. Take a look at our comprehensive " parts manual section" or reach out to our friendly and knowledgeable customer support team for assistance. They'll be more than happy to help you find the perfect fit for your equipment. At our online store, you can easily find other Scag parts in our fast moving parts section. Additionally, if you are looking for parts specifically for your equipment model, you can use our convenient parts lookup feature. We strive to provide a seamless shopping experience for all your outdoor equipment needs.

Food banks and meals | North Northamptonshire Council

Northamptonshire ACRE (Action with Communities in Rural England) will support residents in rural North Northamptonshire who are experiencing severe food or energy poverty and are in crisis while trying to meet their other essential needs. Home-Start Corby is a local community network of trained volunteers and expert support helping families with young children through their challenging times during the cost-of-living crisis. Please verify the original Scag part number in your owner's manual or on the appropriate parts diagram of your model for correct location and fitment of this item. Can provide advice and guidance for those struggling with the cost-of-living. Call your local branch for an appointment on:The Community Law Service offers specialist advice, casework and representation to individuals and families regarding benefits, debt, energy, housing and immigration - including tribunals and court representation. The service is free, independent and confidential: Tingting Zhang , Yue Fei , Bin Meng , Qiongli Zhai , Xiubao Ren , Kai Fu , Xianhuo Wang , Huilai Zhang; Comprehensive Analysis of TP53 Mutation Characteristics and Identification of Patients with Inferior Prognosis and Enhanced Immune Escape in Diffuse Large B Cell Lymphoma. Blood 2021; 138 (Supplement 1): 4485. doi: https://doi.org/10.1182/blood-2021-149899 As well as the organisations above, the Sustainable Food Network also supports organisations and residents living in the area. One way we are doing this is by using SMS messaging. We will send out text messages weekly to people who have recently used our services with a link to the FFT online form. Service Six provides support and essential resource bags for children and young people referred to their services. Online support may also be offered to meet a wide range of problems individuals may be facing.

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Care and Repair provides essential home maintenance and improvement works to eligible vulnerable householders. To access support, you will need to meet eligibility criteria.Methods: We performed a comprehensive analysis of TP53 mutations in the DNA-binding domain (DBD) region. Genome alterations that were mutually exclusive or co-occurring with TP53 mutations were identified, and their potential value in prognosis and possible relationships with tumor microenvironment (TME) were further examined using targeted next-generation sequencing (n=176), transcriptome sequencing (n=152) and circulating tumor DNA sequencing (n=38). Results: TP53 was frequently mutated in DLBCL with a rate of 30% (53 of 176). The occurrence of TP53 mutations was skewed toward the early stages of DLBCL pathogenesis. Among these variants of TP53, 74% were missense mutations, and the remaining were inactivating frameshift indels, nonsense mutations, coding sequencing indels and splicing mutations. Importantly, most mutations (87.5%) occurred in exons 5-8, which encoded the DNA-binding domain (DBD) region of TP53. Codons 175, 273, and 248 of the p53 protein had the highest mutation frequency, which are also the hot spots of TP53 mutation found in most human cancers. However, TP53 alone is insufficient to effectively differentiate the risk of DLBCL, even when only considering mutations in the DBD region. CD58 mutations, which are mutually exclusive from TP53 mutations, in combination with TP53 mutations, could significantly differentiate the prognosis of DLBCL. The survival of patients with either one of the mutually exclusive mutation patterns, namely, TP53MUT&CD58WT or TP53WT&CD58MUT, was inferior to those harboring both wild-type TP53 and CD58. Notably, patients with TP53WT&CD58MUT mutation pattern had the worst outcome and were characterized by a higher overall tumor mutation burden (TMB) and immune score. An enhanced immune escape feature, including the abundant infiltration of inflammatory cells and upregulation of inhibitory immunomodulatory molecules such as PD-1, TIM3, LAG3, KLRC1, KLRC3, KLRD1, IDO1, IDO2 and TDO2, was observed in these patients with TP53WT&CD58MUT mutation pattern. A larger number of terms related to cytokine and chemokine and inflammatory pathways were enriched in the TP53WT&CD58MUT group, including cytokine and chemokine production, binding and activity, and interferon-γ pathway. Additionally, GSEA demonstrated that interferon-α and -γ responses and IL-6/JAK/STAT3 signaling enriched in the TP53WT&CD58MUT group. These patients with TP53WT&CD58MUT mutation pattern represent the candidate populations for immune therapy.

Get in touch | Norfolk and Suffolk NHS Get in touch | Norfolk and Suffolk NHS

You can find out how to get in touch with individual teams by searching our service database. Customer service team Service Six is a Northamptonshire based charity committed to changing lives and creating futures for disadvantaged children, young people and their families. Help in Kettering advertises a wide range of voluntary and community organisations in the Kettering area, that can support you in your time of need. The text will go to service users who are 16 or over, have supplied a valid mobile phone number, and had an appointment recorded by us within the previous week by a team with aFFT code aligned to it. Services users can opt out of receiving the text messages. The next stage may be the provision of self-help information; referral to another, more appropriate organisation; or the making of an appointment for a full interview.

Accommodation Concern will provide practical support to families, couples, and individuals experiencing food or energy poverty in North Northamptonshire: