pirms sporta un sporta laikā ierīvēšanai un masāžai, lai stimulētu asinsriti un atslābinātu muskuļus, palīdzētu novērst vai remdēt muskuļu sāpes un krampjus Should any unwanted side effects occur, stop the use of the product. If symptoms continue, consult your pharmacist or medical doctor.

Over a period of five years, he monitored in his laboratory the continuous improvement of the formulation of a medication, PER-SKIN-DOL “for application – on the skin – for pain”. Ar apļveida kustībām uzsmidzināt nelielu aerosola daudzumu uz sāpju zonas. Izsmidzināt vismaz no 15 cm attāluma. Sakratīt pirms lietošanas. Lūdzu, pirms lietošanas izlasiet lietošanas instrukciju (skatīt vāciņa iekšpusē) un brīdinājumus. The selection of methods and the course of treatment depend on a number of factors, including age, sex, the degree of advancement of degenerative changes, and coexisting diseases. The therapeutic approach should be individually tailored to the needs and physical condition of the patient, and aimed at improving the quality of life and postponing or, if possible, avoiding surgery [ 7, 8]. Physical procedures with the use of direct current, such as galvanic treatment and iontophoresis, are widely used in the treatment of OA [ 8, 9, 10, 11, 12]. PERSKINDOL Thermo Hot Gel sildošais gels satur ēteriskās eļļas, tam sākotnēji ir atvēsinoša iedarbība, kam seko intensīvs sildošs efekts. Tas stimulē asinsriti, atslābina muskuļus, mazina sāpes un veicina atveseļošanās procesu. In the first group, anodic galvanic treatment was performed. In the second group, iontophoresis was performed with the use of Perskindol gel, with the preparation administered from the negative pole of the current (“−” iontophoresis), whereas in the third group, the iontophoresis procedure was performed with the same agent given from the positive pole (“+” iontophoresis).Mentol, 7 različitih etarskihulja (zimzelen, limun, borove iglice, bergamot, pomorandža, ruzmarin, lavanda), terpinol. The study included 100 patients (72 women and 28 men) treated at the Rehabilitation Clinic of the University Hospital of Białystok with diagnosed osteoarthritis of the knee joints. The severity of the lesions was determined according to the Kellgren–Lawrence scale [ 37, 38, 39, 40, 41]. Among the respondents, more than half (56.58%) were patients with 2nd degree degenerative lesions, 27.27% had 1st degree degenerative lesions, and 16.15% had 3rd degree degenerative lesions. The mean age of the patients was 56.16 years. The right knee was affected in 27 patients, the left knee in 29 patients, and both knee joints in 44 patients. The mean duration of pain intensity was 55.78 months (about 4.5 years).

Adults and children from 5 years: apply in thin layers and rub several times a day, according to needs, on the concerned areas. Pine oil and other oils such as bergamot oil, lavender oil, citrus oil, orange peel or rosemary oil also have anti-inflammatory and analgesic properties [ 24, 25, 26, 27, 28, 29, 35]. Several factors influence the effectiveness of the iontophoresis treatment. These include, among others, the physicochemical properties of the compound, i.e., the particle size and charge, the concentration of the substance, and/or the presence of other ions in the preparation. The equipment used for the procedure, the intensity and type of the current flow, the type of electrodes used, and the duration of the procedure are also important. The effect of the therapy also depends on biological factors, such as skin surface area and temperature, and regional blood flow [ 8]. Iontophoresis, due to the introduction of medicinal ions of certain chemical compounds undergoing electrolytic dissociation by force of an electric field, thereby reaching deeper tissues through the skin or mucosa, is a treatment having strong analgesic, anti-inflammatory, and anti-swelling effects. Proper selection of the active electrode is crucial. If an anion is the active ingredient of the drug, the active electrode under which the drug should be placed will be the cathode (“−”), whereas if a cation is the active substance, the drug will be introduced from the anode (“+”). The ions of the substance penetrate the skin through the path of least resistance, i.e., mainly through the sweat glands. It should be emphasized that the advantage of iontophoresis is the fact that a high concentration of the drug can be obtained in the target tissue without the need for oral administration, resulting in a reduced risk of overdose and side effects [ 8, 13, 14, 15]. The literature quotes studies on the use of iontophoresis with NSAIDs and steroid drugs in the treatment of patients with OA [ 8, 9, 10, 11, 12, 13, 42]. A previous study focused on the determination of the current polarization suitable for the introduction of ketoprofen into the rat knee joint [ 47]. Existing studies of NSAIDs showed improvements in walking speed, pain, and active range of motion after 5% Ibuprofen iontophoresis in the management of KO [ 10], and a significant decrease in pain and a significant increase in functional ability and the strength of knee extensor muscles after iontophoresis with Piroxicam gel [ 11]. Moreover, an evaluation of iontophoretic delivery of a cationic ketoprofen choline chloride showed significant pain relief and a reduction in knee inflammation in an osteoarthritic rat model [ 47].

The richest source of plant-based salicylates in Perskindol is wintergreen oil, with its analgesic and anti-inflammatory properties resulting from the inhibition of prostaglandin and nitric oxide synthesis (antioxidant effect) [ 19, 31, 32]. PERSKINDOL Thermo Hot Gel nedrīkst lietot gadījumos, kad ir zināma paaugstināta jutība vai alerģija pret salicilātiem vai kādu citu iepriekšminēto gela sastāvdaļu. Uzliesmojošs.Nelietot uz vaļējām brūcēm un acu tuvumā. Ja nonāk saskarē ar acīm, skalot ar lielu daudzumu ūdens. Nelietot kopā ar gaisa necaurlaidīgām kompresēm vai pārsējiem. Ja PERSKINDOL Thermo Hot Gel ir lietots ilgāk par 21 dienu, ieteicams ievērot trīs dienu pārtraukumu. Pieaugušajiem un bērniem no 5 gadu vecuma. Uzglabāt bērniem neredzamā un nepieejamā vietā. Piesardzības nolūkā jāizvairās no lietošanas grūtniecības un zīdīšanas laikā. Ja rodas jebkādas blakusparādības, lietošana nekavējoties jāpārtrauc. Ja simptomi saglabājas, lūdzu, konsultējieties ar ārstu vai farmaceitu. Uzglabāt temperatūrā līdz 25 °C. Pēc katras lietošanas cieši aizveriet iepakojumu. Nelietojiet PERSKINDOL Thermo Hot Gel pēc uz iepakojuma norādītā lietošanas termiņa beigām (smilšu pulksteņa simbols). afaceri elvetian al carui scop a fost sa creeze un antiinflamator topic eficient pe care sa il poata folosi in timpul partidelor de tenis pentru ameliorarea durerilor, fara risc de dopaj. Applying Perskindol Active Gel has a unique dual action: it provides an immediate cooling and soothing action; while massaging it helps to stimulate blood circulation and to relax the muscles. Moreover, the administration of drugs with the use of iontophoresis is recognized as an alternative in the treatment of OA [ 14].