The method of diagnosis of NAFLD included biopsy, transaminases, and imaging methods including ultrasound, elastography, CT examination, or a combination of these methods. It contains liver supportive nutrients such as taurine and apple extract along with the antioxidants alpha lipoic acid and green tea extract. Many are the therapeutic activities carried out on the liver: cholagogue effect, choleretic effect, analgesic and antispasmodic effects on the bile ducts. We excluded randomised clinical trials in which participants had previously undergone liver transplantation.

We planned to assess the presence of clinical heterogeneity by comparing effect estimates (please see Subgroup analysis and investigation of heterogeneity) in trial reports based on the presence of diabetes and NASH, and based on the co‐interventions (e. It is not possible for us to draw any conclusions about you, and any data collected as a result will never be passed on to third parties. The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network. A total of 60 trials were at low risk of attrition bias, as there were no post‐randomisation dropouts, or an intention‐to‐treat analysis was used; 129 trials were at unclear risk of attrition bias because it is not clear whether there were post‐randomisation dropouts, or whether post‐randomisation dropouts were related to outcomes (if there were post‐randomisation dropouts); the remaining 13 trials were at high risk of attrition bias, as post‐randomisation dropouts were probably related to the intervention and to outcomes.None of the trials reported that they measured overall health‐related quality of life using a validated scale. We updated the list mentioned in the protocol to include any nutritional supplementation used primarily for treatment of NAFLD. The risk of bias is presented at trial level, as assessments at outcome level for clinical outcomes were the same. BioCare Antioxidant Complex is a potent and synergistic combination of natural plant extracts including flavonoids and carotenoids, with alpha lipoic acid and vitamin C, providing optimum antioxidant support.

The transitivity assumption means that participants included in different trials with different treatments (in this case, for NAFLD) can be considered as part of a multi‐arm randomised clinical trial and could potentially have been randomised to any of the interventions ( Salanti 2012). Looking for a place, where you could get all the necessary pharma and wellness products without leaving the comfort of your home?High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Various interventions have been used in attempts to treat people with NAFLD, including nutritional supplementation (probiotics, prebiotics, synbiotics, vitamin supplementation, polyunsaturated fatty acid supplementation) ( Nabavi 2014; Sharifi 2014; Li 2015; Nogueira 2016; Mofidi 2017); lifestyle modifications such as dietary changes and exercise training (not included in this review) ( Abenavoli 2015; Shojaee‐Moradie 2016; Zhang 2016; Houghton 2017); pharmacological interventions (not included in this review) ( Lombardi 2017); and weight reduction surgery (bariatric surgery) (not included in this review) for obese people with NAFLD ( Adorini 2012; Anstee 2012; Chalasani 2012; Paschos 2012; Abenavoli 2013).

In a study that followed people with simple steatosis and NASH for a mean of 28 years, similar rates of mortality were observed between participants with simple steatosis and NASH groups, but higher mortality rates were noted in people with severe fibrosis regardless of whether they had bland steatosis or NASH ( Soderberg 2010). If you are taking medicine or other food supplements always check with your doctor and or healthcare practitioner before changing your diet or starting a new supplement regime. The weighted median control group proportion shown in this table was from the only study in which a formal analysis was performed.This Review looked at people of any sex, age, and ethnic origin, with non‐alcohol‐related liver disease. The evidence is very uncertain about effects of interventions in any of the remaining comparisons, or data were sparse (with zero events in at least one of the groups), precluding formal calculations of effect estimates. Therefore increased mortality among people with NAFLD may be related to metabolic syndrome, rather than to NAFLD alone. If the cell corresponding to B versus A is also missing in direct comparisons, this means that there was no direct comparison. When possible, we explored substantial clinical, methodological, or statistical heterogeneity and addressed the heterogeneity in subgroup analyses (see Subgroup analysis and investigation of heterogeneity).