Maheu E, Rannou F, Reginster JY. Efficacy and safety of hyaluronic acid in the management of osteoarthritis: evidence from real-life setting trials and surveys. Seminars in Arthritis and Rheumatism. 2016;45(4):S28-S33. doi:10.1016/j.semarthrit.2015.11.008 Q+A Hyaluronic Acid Daily Moisturiser refreshes your complexion with the best hydrating ingredients! Whilst the word 'acid' might seem scary, we produce Hyaluronic Acid naturally in our own bodies, as it helps to keep our skin hydrated! Oe M, Sakai S, Yoshida H, et al. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Clinical, Cosmetic and Investigational Dermatology. 2017;10:267-273. doi:10.2147/CCID.S141845

Monfort J, Rotés-Sala D, Segalés N, et al. Comparative efficacy of intra-articular hyaluronic acid and corticoid injections in osteoarthritis of the first carpometacarpal joint: results of a 6-month single-masked randomized study. Joint Bone Spine. 2015;82(2):116-121. doi:10.1016/j.jbspin.2014.08.008 Yang Z, Li M, Xiao L, Yi Z, Zhao M, Ma S. Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis. Brazilian Journal of Medical and Biological Research. 2020;53(8):e9886. doi:10.1590/1414-431X20209886 Osteoarthritis: In a randomized study comparing the effect of intra-articular (within the joint) HA injection to betamethasone injection, people with osteoarthritis of the thumb underwent one cycle of three injections (one per week) of 0.5 cubic centimeters (cm 3) of HA 5 milligrams (mg). Intra-articular HA injection requires a prescription and is given as a shot to your knee joint by a trained healthcare professional. Oliviero F, Ramonda R, Hoxha A, et al. Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study. Reumatismo. 2020;72(3):125-130. doi:10.4081/reumatismo.2020.1272Hsu TF, Su ZR, Hsieh YH, et al. Oral hyaluronan relieves wrinkles and improves dry skin: a 12-week double-blinded, placebo-controlled study. Nutrients. 2021;13(7):2220. doi:10.3390/nu13072220 Fibromyalgia: Blood levels of HA were measured in 69 Korean people designated female at birth with fibromyalgia, and it was found that the levels did not differ from those in the control group. Thus, the study indicated that HA levels did not correlate with disease severity.

Allergy to avian or avian-derived products: HA may be derived from rooster combs. Caution is advised if you have an allergy to eggs, feathers, or poultry. In addition to obtaining HA from animals, HA can also be obtained from bacteria. Mikosinski J, Di Landro A, Kasztalska-Kazmierczak K, et al. Efficacy and safety of a hyaluronic acid-containing cream in the treatment of chronic, venous, or mixed-origin leg ulcers: a prospective, multicenter randomized controlled trial. Wounds. 2021;33(11):285-289. Children: Studies have been performed to evaluate the efficacy of HA inhalation in the treatment of the upper and lower airways in children, but evidence of such efficacy is limited. Moreover, topical HA gel has been studied in children to treat mouth ulcers. Despite the use of HA in children, the safety of the consumption of HA by mouth in children is yet to be known.

Reviews

Majeed M, Majeed S, Narayanan NK, Nagabhushanam K. A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytotherapy research: PTR. 2019;33(5):1457-1468. doi:10.1002/ptr.6338 How to recycle: Remove the lid from the tube. Wash out the tube and dry. Both our lids and tubes are 100% recyclable so can be disposed of in your domestic recycling.