Diuretic activity is associated with the aqueous extracts of C. papaya. Adult male Sprague-Dawley rats were given an oral dose of 10 mg/kg of C. papaya root extracts. The demonstrated increased urine output ( P<0.01) was similar to effects with hydrochlorothiazide 10 mg/kg. Sripanidkulchai 2001

Ukoliko Zahtjev šaljete putem e-pošte isti će biti obrađen isključivo ako je poslan sa Vaše postojeće e-pošte koju imamo evidentiranu u našem informacijskom sustavu. Podaci koje ćete dati na ovom obrascu koristiti će se isključivo u svrhe identificiranja osobnih podataka koje tražite i odgovora na Vaš zahtjev. Rješavanje nesporazuma ili dodatna pitanja

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Vaše osobne podatke možemo dati našim pouzadnim partnerima koji održavaju naš informacijski sustav ili prušaju usluge u naše ime primjerice za marketing, financije, obrade plaćanja te isporuku naručenih proizvoda. Svi vanjski partneri su dužni temeljem relevantnih ugovora koristiti osobne podatke koji su im povjereni u skladu s našim politikama i smjernicama za obradu osobnih podataka. Rheological studies were conducted with Caricol ®-Gastro, oat I and oat II. To prevent liquid evaporation a built-in evaporation protection hood was used for all measurements. The linear viscoelastic region (LVE) was determined via frequency sweep between 0.1 and 100 Hz and amplitude sweep at a constant angular frequency of 0.1 rad/s and deformation (γ) between 0.1 to 100. The viscoelastic moduli G’ (i.e., elastic modulus) and G’’ (i.e., viscous modulus) were determined via strain-controlled oscillation using a Physica MCR 301 rheometer (Anton Paar) with a CP-50-1 measurement system (cone-plate geometry) at RT (25 ± 0.5 °C) and 37 ± 0.5 °C [ 42]. The loss factor tanδ, which describes the ratio of viscous and elastic behavior, was calculated according to G’’/G’ for each measurement point. Viscosity η was determined using the same measurement system with shear rate-controlled rotation at both 25 ± 0.5 °C and 37 ± 0.5 °C. The applied shear strain for both experiments were angular frequencies between 0.1 and 100 1/s to consider naturally occurring strain due to gastric motility [ 43]. At an increased oat flour concentration (oat II), the ratio of the viscoelastic moduli shifted, more specifically, the elastic modulus was larger than the viscous modulus resulting in an increased network stability. The network became tighter and the pore size distribution shifted towards smaller values (highest volume parentage: 3600–4800 nm). However, the observed network still seemed less stable than that of Caricol ®-Gastro. When mixed with SGF the network did not change. The adhesive studies showed that a higher adhesion to mucins was observed than for oat I, but the interactions were significantly ( p< 0.01) weaker than in Caricol ®-Gastro. Again, spreadability could not be confirmed in vitro because of agglutination of the syringe. The ex vivo studies showed that due to the stable viscoelastic network comparable results to Caricol ®-Gastro were obtained after 10 min. However, after 30 min the network loosened and adhesion decreased. In this study the participants were volunteers, with chronic (prevailing) indigestions and dysfunctions in the gastrointestinal tract. During the trial the intake of the substance of intent and placebo was 20 ml daily for 40 days. The endpoints were the frequency of 22 symptoms recorded before and after the documented intake recorded by questionnaire.

Papaya is contraindicated in patients with known hypersensitivity to any of its components (eg, papain). Treća strana – fizička ili pravna osoba, tijelo javne vlasti, agencija ili drugo tijelo koje nije ispitanik, voditelj obrade, izvršitelj obrade ni osobe koje su ovlaštene za obradu osobnih podataka pod izravnom nadležnošću voditelja obrade ili izvršitelja obrade.For example, a 2010 animal study found a papain-based wound cleanser helped promote wound healing in rats. A 2012 systematic review of studies also concluded papain is effective and safe in treating many types of wounds in various stages of healing. Most of the research is still preliminary.

Nadzorno tijelo – Agencija za zaštitu osobnih podataka je državna agencija čiji je zadatak štititi podatke i privatnost, nadgledati procese primjene Uredbe, te aktivno provoditi Uredbu o zaštiti osobnih podataka. Prikupljanje i svrha obrade osobnih podataka obrada je nužna za izvršavanje ugovora u kojem je Ispitanik stranka ili kako bi se poduzele radnje na zahtjev Ispitanika prije sklapanja ugovoraMacrorheological Measurements Taking into Account Interactions with Simulated Gastric Fluid and Gastric Mucins conține fructe de papaya coapte preparate bio, ovăz preparat organic și concentrat din suc de mere;