Drug Addiction Research and the Health of Women – pg. 33–52" (PDF). Archived from the original (PDF) on August 22, 2008 . Retrieved March 21, 2010. In 2021, the International Agency for Research on Cancer concluded that opium is a Group 1 (sufficient evidence) human carcinogen, causing cancers of the larynx, lung, and urinary bladder. [154] Slang terms [ edit ]

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Brzezinski, Matthew. "Re-Engineering the Drug Business". The New York Times Magazine, June 23, 2002 Both analgesia and drug addiction are functions of the mu opioid receptor, the class of opioid receptor first identified as responsive to morphine. Tolerance is associated with the superactivation of the receptor, which may be affected by the degree of endocytosis caused by the opioid administered, and leads to a superactivation of cyclic AMP signaling. [152] Long-term use of morphine in palliative care and the management of chronic pain always entails a risk that the patient develops tolerance or physical dependence. There are many kinds of rehabilitation treatment, including pharmacologically based treatments with naltrexone, methadone, or ibogaine. [153] Albert D. Fraser & David Worth (October 1999). "Experience with a Urine Opiate Screening and Confirmation Cutoff of 2000 mg/ml". Journal of Analytical Toxicology. 23 (6): 549–551. doi: 10.1093/jat/23.6.549. PMID 10517566. Morewood, Samuel (1838). A philosophical and statistical history of the inventions and customs of ancient and modern nations in the manufacture and use of inebriating liquors; with the present practice of distillation in all its varieties: together with an extensive illustration of the consumption and effects of opium, and other stimulants used in the East, as substitutes for wine and spirits. Dublin, W. Curry and W. Carson. The renowned Andalusian ophthalmologic surgeon Abu al-Qasim al-Zahrawi ("Abulcasis", 936–1013 CE) relied on opium and mandrake as surgical anesthetics and wrote a treatise, al-Tasrif, that influenced medical thought well into the 16th century. [23]Huxtable Ryan J.; Schwartz Stephen K. W. (2001). "The Isolation of Morphine—First Principles in Science and Ethics". Molecular Interventions. 1 (4): 189–191. PMID 14993340. a b c d e Alfred W. McCoy. "Opium History, 1858 to 1940". Archived from the original on April 4, 2007 . Retrieved May 4, 2007.

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Chouvy, P.A. (2009). "Opium. Uncovering the Politics of the Poppy, London, I.B. Tauris (Cambridge, Harvard University Press: 2010)". Archived from the original on October 26, 2011. William Travis Hanes; Frank Sanello (2004). Opium Wars: The Addiction of One Empire and the Corruption of Another. Sourcebooks, Inc. pp.78–. ISBN 978-1-4022-0149-3.Abu Bakr Muhammad ibn Zakariya al-Razi (841–926)". Saudi Aramco World. January 2002 . Retrieved January 12, 2008. Map showing the amount of opium produced in China in 1908: The quote "We English, by the policy we have pursued, are morally responsible for every acre of land in China which is withdrawn from the cultivation of grain and devoted to that of the poppy; so that the fact of the growth of the drug in China ought only to increase our sense of responsibility." is by Lord Justice Fry. Withdrawal symptoms usually start six to 24 hours after the last dose and can last around seven to ten days. These symptoms are described as flu-like, and can include: The earliest clear description of the use of opium as a recreational drug in China came from Xu Boling, who wrote in 1483 that opium was "mainly used to aid masculinity, strengthen sperm and regain vigor", and that it "enhances the art of alchemists, sex and court ladies". He also described an expedition sent by the Ming dynasty Chenghua Emperor in 1483 to procure opium for a price "equal to that of gold" in Hainan, Fujian, Zhejiang, Sichuan and Shaanxi, where it is close to the western lands of Xiyu. A century later, Li Shizhen listed standard medical uses of opium in his renowned Compendium of Materia Medica (1578), but also wrote that "lay people use it for the art of sex," in particular the ability to "arrest seminal emission". This association of opium with sex continued in China until the end of the 19th century.

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Opium poppies are popular and attractive garden plants, whose flowers vary greatly in color, size and form. A modest amount of domestic cultivation in private gardens is not usually subject to legal controls. In part, this tolerance reflects variation in addictive potency. A cultivar for opium production, Papaver somniferum L. elite, contains 91.2 percent morphine, codeine, and thebaine in its latex alkaloids, whereas in the latex of the condiment cultivar "Marianne", these three alkaloids total only 14.0 percent. The remaining alkaloids in the latter cultivar are primarily narcotoline and noscapine. [114] Chandra, Siddharth (2008). "Economic Histories of the Opium Trade". Archived from the original on September 28, 2013. Hideyuki Takano; The Shore Beyond Good and Evil: A Report from Inside Burma's Opium Kingdom (2002, Kotan, ISBN 0-9701716-1-7) Office of the Commissioner. "Legislation – Controlled Substances Act". Fda.gov . Retrieved January 25, 2017.

Nye, Gideon (1873). The morning of my life in China: comprising an outline of the history of foreign intercourse from the last year of the regime of honorable East India Company, 1833, to the imprisonment of the foreign community in 1839. Between 400 and 1200 CE, Arab traders introduced opium to China, and to India by 700. [19] [1] [12] [20] The physician Muhammad ibn Zakariya al-Razi of Persian origin ("Rhazes", 845–930 CE) maintained a laboratory and school in Baghdad, and was a student and critic of Galen; he made use of opium in anesthesia and recommended its use for the treatment of melancholy in Fi ma-la-yahdara al-tabib, "In the Absence of a Physician", a home medical manual directed toward ordinary citizens for self-treatment if a doctor was not available. [21] [22]

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In June 2007, the council launched a "Poppy for Medicines" project that provides a technical blueprint for the implementation of an integrated control system within Afghan village-based poppy for medicine projects: the idea promotes the economic diversification by redirecting proceeds from the legal cultivation of poppy and production of poppy-based medicines. [140] There has been criticism of the Senlis report findings by Macfarlan Smith, who argue that though they produce morphine in Europe, they were never asked to contribute to the report. [141] Cultivation in the UK [ edit ] Production of thebaine and oripavine". April 20, 2004. Archived from the original on September 5, 2012 . Retrieved May 10, 2007. Richard Askwith; The Sunday Times (September 13, 1998). "How aspirin turned hero" . Retrieved May 2, 2007. Merlin, M. D. (September 2003). "Archaeological Evidence for the Tradition of Psychoactive Plant Use in the Old World". Economic Botany. 57 (3): 295–323. doi: 10.1663/0013-0001(2003)057[0295:aeftto]2.0.co;2. ISSN 0013-0001. JSTOR 4256701. S2CID 30297486 . Retrieved May 31, 2022. Poppy seeds are a common and flavorsome topping for breads and cakes. One gram of poppy seeds contains up to 33 micrograms of morphine and 14 micrograms of codeine, and the Substance Abuse and Mental Health Services Administration in the United States formerly mandated that all drug screening laboratories use a standard cutoff of 300 nanograms per milliliter in urine samples. A single poppy seed roll (0.76grams of seeds) usually did not produce a positive drug test, but a positive result was observed from eating two rolls. A slice of poppy seed cake containing nearly five grams of seeds per slice produced positive results for 24 hours. Such results are viewed as false positive indications of drug use and were the basis of a legal defense. [116] [117] On November 30, 1998, the standard cutoff was increased to 2000 nanograms (two micrograms) per milliliter. [118] Confirmation by gas chromatography-mass spectrometry will distinguish amongst opium and variants including poppy seeds, heroin, and morphine and codeine pharmaceuticals by measuring the morphine:codeine ratio and looking for the presence of noscapine and acetylcodeine, the latter of which is only found in illicitly produced heroin, and heroin metabolites such as 6-monoacetylmorphine. [119] Harvesting and processing [ edit ] Harvesting opiumSantella, Thomas M.; Triggle, D. J. (2009). Opium. Facts On File, Incorporated. p.8. ISBN 9781438102139. Presley CC, Lindsley CW. DARK Classics in Chemical Neuroscience: opium, a historical perspective. ACS Chemical Neuroscience. 2018;9(10):2503-18. Derks, Hans: History of the Opium Problem: The Assault on the East, ca. 1600–1950. Sinica Leidensia, 105. Leiden: Brill, 2012. ISSN 0169-9563. ISBN 978-90-04-22158-1