Ribeiro, M.G.T.C., Machado, A.A.S.C., Metal-Acetylacetonate Synthesis Experiments: Which Is Greener?, J. Chem .Educ., 88, 947-953, 2011. Food supplement: The recommended daily dosage should not be exceeded. Not a substitute for a balanced and varied diet and a healthy lifestyle. Copper sulfate pentahydrate (1g, 4 mmol) was dissolved in 8.5 mL of 1M HCl at room temperature and glycine powder (0.7g, 9.3 mmol) was slowly added while stirring. The solution was then kept in a water bath and its temperature was maintained at around 55°C. After 30 minutes of heating, about 1.5 – 2g of NaHCO 3 was added slowly to the solution until a blue precipitate was formed. The precipitate was washed with small portions of ethanol (3 to 4 portions of 3 mL each) and dried under vacuum and in an oven at 80°C for 10 minutes. Subcutaneous copper injections can help normalize blood copper levels, but whether these help to normalize brain copper levels depends on the type of genetic mutation involved.

Copper is an essential trace element that is vital to human life. Due to developments over the last century, copper has, for many people, become either insufficient in their diet and/or sabotaged by excessive iron and other chemicals introduced to use. Claims that copper supplements are effective in the treatment of arthritis or skin conditions have not been proven. Use of copper supplements to cause vomiting has caused death and should be avoided. Kinen, C.O., Rossi, L. I., de Rossi, R.H., The Development of an Environmentally Benign Sulfide Oxidation Procedure and its Assessment by Green Chemistry Metrics, Green Chem., 11, 223-228, 2009.Bis(glycinato)copper(II) is typically prepared from the reaction of copper(II) acetate in aqueous ethanol with glycine: [2] [3] Cu(OAc) 2 + 2 H 2NCH 2COOH + x H 2O → [Cu(H 2NCH 2COO) 2(H 2O) x] + 2 AcOH, x = 0 or 1 While it’s not always obvious, some supplements can contain animal-derived ingredients, making the product unsuitable for vegans. All forms of the complex have been characterized crystallographically, the most commonly isolated one being the cis monohydrate ( x = 1). [5] [1] Sufficient copper in the diet may help prevent cardiovascular disease and osteoporosis, too. Cardiovascular health

In the calculation of the green metrics for the cis product, the environmental factor (E factor) was calculated by measuring the weight of the total amount of waste generated, inclusive of the ethanol and water used to wash the samples. Thus the E factor was very high in both the protocols. Again, in the measurement of Mass Intensity (MI), water and ethanol, which were used as solvents in the reaction, were considered in the total mass of the reagents (although some calculations disregard the mass of water, we had it involved here). Nevertheless, the greenness of the reactions were reflected by the high percentages of the indices Atom Economy (AE), Atom Utilisation (AU), Relative Mass Efficiency (RME) and Copper Element Efficiency (CuEE). Copper cannot be produced in the body, so it must be consumed through diet or supplementation. Copper can be found in foods such as liver, oysters, shiitake mushrooms and nuts. Who is Copper Bisglycinate suitable for?Copper citrate is the most common type of dietary copper used on the market. This substance is cheap to mass-produce, but there are some concerns about its bioavailability. Copper bisglycinate, however, is bonded to a glycerin substrate, and it absorbs directly into the bloodstream. This type of copper has much higher bioavailability than copper citrate, but scientists aren’t sure yet exactly how much better the absorption of copper bisglycinate might be.