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In the Los Angeles Times, Justin Chang wrote that "With its grotesque design choices and busy, metronomic editing, Cats is as uneasy on the eyes as a Hollywood spectacle can be, tumbling into an uncanny valley between mangy realism and dystopian artifice." [90] Debruge said that the film should have used "face paint and Lycra" like the musical. [86] SNV minor allele frequency (MAF) distributions were compared across each constraint group. MAFs for synonymous SNVs were similarly distributed in all constraint groups. Conversely, the distribution of nonsynonymous SNVs increasingly skewed toward lower MAFs under stronger levels of constraint. For example, 25.5% of LoF SNVs in genes under weak constraint have a MAF < 1%, whereas 35.9% of LoF SNVs in genes under strong constraint have a MAF < 1% ( Fig 2B). To determine whether these shifts in MAFs were significant, the fraction of SNVs in a singleton state were compared to expected levels based on random assignment of singleton states. Singleton states of SNVs were significantly enriched for nonsynonymous SNVs with enrichment levels increasing under stronger constraint, indicating many SNVs with functional impacts in genes under constraint are likely rare ( Fig 2C). Together, these results show a significant association between selection in human genes and SNV accumulation in cats, suggesting selection pressure within cats and humans is similar across orthologous genes. ThatHashTagShow (13 June 2018). "EXCLUSIVE: Anne Hathaway In Talks To Star In Universal's CATS". That Hashtag Show. Archived from the original on 17 November 2018 . Retrieved 21 February 2019. Jennifer Hudson Performs "Memory" During 'Cats' CinemaCon Presentation". The Hollywood Reporter. Archived from the original on 6 April 2019 . Retrieved 4 March 2019.

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