Wu,Y.; Vora,L.K.; Wang,Y.; Adrianto,M.F.; Tekko,I.A.; Waite,D.; Donnelly,R.F.; Thakur,R.R.S. Eur.J.Pharm.Biopharm. 2021, 165, 306–318. doi:10.1016/j.ejpb.2021.05.022

Datta,D.; Roy,G.; Garg,P.; Venuganti,V.V.K. J.DrugDeliverySci.Technol. 2022, 70, 103211. doi:10.1016/j.jddst.2022.103211 Larrañeta,E.; Lutton,R.E.M.; Woolfson,A.D.; Donnelly,R.F. Mater.Sci.Eng.,R 2016, 104, 1–32. doi:10.1016/j.mser.2016.03.001 Prausnitz,M.R.; Jiang,N.; Edelhauser,H.F. Method for Drug Delivery to Ocular Tissue Using Microneedle. WO2007131050A3, Feb 14, 2008.In a subsequent work, the authors presented two types of patches for the delivery of triamcinolone acetonide (TA), a model steroidal drug applied in numerous inflammatory conditions to the posterior segment of the eye. A microneedle scleral patch (MSP) and a microneedle corneal patch (MCP) were obtained by micromolding with the use of PVP. The ex vivo experiments performed on porcine eye globe showed that, in comparison to MCP and TA nanosuspension, MSP yielded much greater TA concentrations in the vitreous humor and choroid-retinal complex after 5 min of application. Moreover, the patches were tested with a rabbit eye model. In this case, after 24 h, significantly higher TA accumulation was observed for MSP in comparison to MCP and intravitreal injection [175]. Moffatt,K.; Wang,Y.; RajSingh,T.R.; Donnelly,R.F. Curr.Opin.Pharmacol. 2017, 36, 14–21. doi:10.1016/j.coph.2017.07.007 Sadeqi,A.; Kiaee,G.; Zeng,W.; RezaeiNejad,H.; Sonkusale,S. Sci.Rep. 2022, 12, 1853. doi:10.1038/s41598-022-05912-6

Microneedles are a really clever way of increasing the delivery of skincare actives that can’t be done with conventional skincare products. The needles go through the skin barrier and create little tunnels for the ingredients to get through. Simultaneously with the development of single-microneedle technologies, research is focused on microneedle systems/patches for ocular drug delivery. Initially, such arrays were considered as painless, non-invasive, and highly efficient alternative for transdermal, intradermal, and percutaneous delivery of drugs [8,101,102]. Recently, it has been found that they can be successfully applied to the cornea or sclera [103]. Microneedles in skin administration have been studied for many years, including delivery of various therapeutic agents. These included antibiotics [104,105] or antifungals [106] for the treatment of local skin infections but also other drugs intended to achieve systemic action, for example, non-steroidal anti-inflammatory drugs (NSAIDs) [107], antihypertensives [108], and lipid-lowering drugs [109]. Moreover, microneedles (MNs) are broadly investigated as very promising platforms for the delivery of large molecules such as insulin [110] or nucleic acids [111,112]. Another application for which MNs have great potential is vaccine delivery [113-116]. The use of MNs in ophthalmology can still be considered as a fledgling area, however, with great potential but also many unknowns. The presented review summarizes the current data on ophthalmic microneedle patches, their manufacturing techniques, and the obtained therapeutic efficacy. In addition to a number of advantages, the questionable aspects related to this dosage form are also discussed. 2 Types of microneedle: materials, fabrication and properties for drug delivery 2.1 Microneedle system types and properties Complete with 450 dissolving microneedles, these patches transform dull, textured under-eyes to reveal a smoother, youthful complexion. Active ingredients work to diminish fine lines over time, while vitamin C boosts tone and stimulates the production of fresh collagen. Finally, a seven-peptide blend strengthens and supports a healthy skin barrier. It’s worth trying these on smile lines, too, as well as your forehead or anywhere else that’s prone to wrinkles. Among the ophthalmic preparations, the most commonly used are eye drops [49-51], ointments [52,53], or gels [54,55], containing the drug in a dissolved or suspended form [56,57]. They are applied by medical personnel or by the patient himself to the surface of the eye, to the conjunctival sac, or on the eyelid. Their main disadvantage is the need for frequent dosing, which can be troublesome. Hence, the treatment regimen is rarely followed, leading to a reduction in the effectiveness of the therapy [58,59]. Therefore, apart from designing the vehicle/base composition, drugs are often incorporated into appropriate carriers or introduced into systems whose purpose is to provide the expected concentration in the treated tissue for the desired time period. The most frequently studied and described are liposomes [60,61], micelles [60,62], microparticles [63-65], nanoparticles [66,67], micro- [68,69], and nanoemulsions [70,71]. Unfortunately, it has to be noticed that most technological solutions on the nanoscale are only promising at the laboratory stage. The transfer of such technologies to an industrial scale is often complicated and causes many difficulties [72-74].

Pineda-Álvarez,R.A.; Bernad-Bernad,M.J.; Rodríguez-Cruz,I.M.; Escobar-Chávez,J.J. J.Pharm.Innovation 2022, 17, 71–84. doi:10.1007/s12247-020-09494-6

Chang,M.-C.; Luo,T.-Y.; Huang,C.-Y.; Peng,C.-L.; Chen,K.-Y.; Yeh,L.-K. Biomed.Phys.Eng.Express 2020, 6, 045017. doi:10.1088/2057-1976/ab97a2

Liu,G.-S.; Kong,Y.; Wang,Y.; Luo,Y.; Fan,X.; Xie,X.; Yang,B.-R.; Wu,M.X. Biomaterials 2020, 232, 119740. doi:10.1016/j.biomaterials.2019.119740 We have a 30-day return policy, which means you have 30 days after receiving your item to request a return.

A few studies have found that dissolving microneedle patches worked better than essences with the same ingredients: Hi, these sound so cool! But reading these breakthroughs always gives me mild anxiety about my current skincare regimen. Gote,V.; Sikder,S.; Sicotte,J.; Pal,D. J.Pharmacol.Exp.Ther. 2019, 370, 602–624. doi:10.1124/jpet.119.256933 Li,J.; Liu,B.; Zhou,Y.; Chen,Z.; Jiang,L.; Yuan,W.; Liang,L. PLoSOne 2017, 12, e0172043. doi:10.1371/journal.pone.0172043 Depending on the size of the needles, microneedles can be used as a non-invasive home skin care and has been gaining popularity in the form of roller devices and skin patches.

Dugam,S.; Tade,R.; Dhole,R.; Nangare,S. FutureJ.Pharm.Sci. 2021, 7, 19. doi:10.1186/s43094-020-00176-1 agree that the result from Vice Reversa Eye Rejuvenator is better and faster than traditional eye creams