The contained vitamin B2 serves to maintain normal mucosal function and helps to protect the cells from oxidative stress.

The test substance used in the proprietary studies is pasteurised Akkermansia muciniphila (strain ATCC BAA-835), manufactured by the applicant. After birth, it begins to colonise the intestine and already reaches a level similar to that of an adult in the first year of the child’s life. The intestine is the health centre of our body: billions of intestinal bacteria work every day to ensure that digestion and the body’s defences function optimally. This is because Akkermansia consumes mucins and then turns them into certain types of short-chain fatty acids .We plan to invest in the development and management of observational studies in close collaboration with the prescribers. The preliminary 14-day dose rage-finding study in Crl:wI(Han) rats was performed to evaluate potential short-term toxicity of the novel food and to select dose levels for use in the 90-day study. The specification for this novel food diverges from this advice, where it has been set at less than 500 colony forming units per gram (<500cfu/g). On the same day of the following month your card will be charged the second payment and so on for each remaining month of the purchase plan. The evidence for this can be found on pages 45 to 47 of Annex A; the full study report and results can be found attached within Annex D.

Well there are no natural sources of akkermansia, and no akkermansia supplement, it is about providing substrate/food for it to flourish. Species identification using 16s rRNA gene sequencing has also been performed to confirm the identity of each of the five independent batches, all of which conform to the specification. The authors of this study concluded, that the intervention was safe and well tolerated and that supplementation with A. The applicant states that all proprietary studies carried out are GLP-compliant and follow OECD guidelines. The European Food Safety Authority ( EFSA) has established a framework known as the Qualified Presumption of Safety (QPS) concept which provides a generic assessment system that can be applied to all requests received for the safety assessments of microorganisms deliberately introduced into the food chain.Xu Y, Wang N, Tan H-Y, Li S, Zhang C and Feng Y (2020) Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems. Yes, but late in the manufacturing process, the Akkermansia muciniphila is freeze-dried, which evaporates all the water. The tested batches all conform with the specification and the applicant states this is in part due to the way the product is produced not allowing the growth or survival of other microbes. In this context, prebiotics are defined as “a substrate that is selectively utilised by host microorganisms conferring a health benefit”.

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LPS is a major component of the outer membrane of gram-negative bacteria and its presence (or excess presence) in circulation often indicates leaky gut, thus a disruption of intestinal mucus. While we don’t ship to other countries, we're building a network of third-party partners who will offer our products in other countries. A recent study on polyphenols details how cranberry extract triggers a unique response from the intestinal mucus layer.A graduate of Brighton’s College of Naturopathic Medicine, she is committed to fighting the root causes of chronic illness and bringing functional medicine to everyone who needs it.