A. Vogel Neem Cream | Can be Used on Eczema-prone Skin | Naturally conditions and moisturises dry or very dry skin | 50g

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Similarly, one man experienced neurological and psychotic symptoms after consuming 2.1 ounces (60 mL) of neem oil ( 23). NgoHTT, et al. (2017). Topical application of neem leaves prevents wrinklesformation in UVB-exposed hairless mice. DOI: Oxidative stress is caused by a buildup of unstable molecules called free radicals. Although your body naturally produces free radicals as a byproduct of metabolism, external sources increase their presence. Neem seed oil is rich in fatty acids, including oleic, stearic, palmitic, and linoleic acids. Collectively, these fatty acids have been shown to have anti-inflammatory, antioxidant, and antimicrobial properties that promote healthy skin ( 19). Neem’s antioxidant and anti-inflammatory properties may help fight oxidative stress, which may in turn promote liver and kidney health.

Mishra A, Dave N. Neem oil poisoning: case report of an adult with toxic encephalopathy. Indian J Crit Care Med. 2013;17(5):321–322. doi:10.4103/0972-5229.120330 AlzohairyM. (2016). Therapeutics role of Azadirachta indica (neem) and their activeconstituents in diseases prevention and treatment. DOI:Some drugs, including cancer medication, painkillers, and antipsychotics, may contribute to oxidative stress, leading to tissue damage in your liver and kidneys ( 16).

Before putting neem oil on your face, do a patch test on your arm. If within 24 hours you don’t develop any signs of an allergic reaction — such as redness or swelling — it should be safe to use the oil on other areas of your body. Neem has been shown to have long-term contraceptive effects in men after a single dose. Due to its ability to halt sperm development and the limited research into its safety, you should avoid neem if you’re trying to have children ( 27). Free radical damage can contribute to the hyperpigmentation we see as we age. So, if you’re experiencing discolouration, redness, and uneven skin tone, you might benefit from neem oil. Jalaluddin M, Rajasekaran UB, Paul S, et al. Comparative evaluation of neem mouthwash on plaque and gingivitis: a double-blind crossover study. J Contemp Dent Pract. 2017;18(7):567-571. doi:10.5005/jp-journals-10024-2085A test-tube study showed that neem oil may aid long-term acne treatment when added to solid lipid nanoparticles (SLNs), a new type of drug formulation that offers a stable release of active ingredients ( 21). In some cases, infants have experienced severe poisoning after being given neem oil at doses of 0.18–1.06 ounces (5–30 mL) ( 30, 31). Barua, C. C., et al. (2010). Evaluation of the wound healing activity of methanolic extract of Azadirachta indica and Tinospora cordifolia (guduchi) in rats. Neem may have several other health benefits, though results are mixed, and further studies in people are necessary. Antimalarial effects