NTG Shockproof Designed for iPhone 11 Case [2 Layer Structure Protection] [Military Grade Anti-Drop] Lightweight Shockproof Protective Phone Case for iPhone 11 6.1 inch, Red

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Yang, Y.; Sun, X. Retinal Ganglion Cell Death in Glaucoma: Advances and Caveats. Curr. Eye Res. 2023, 48, 1–10. [ Google Scholar] [ CrossRef]

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Initiatives

Boccuni, I.; Fairless, R. Retinal Glutamate Neurotransmission: From Physiology to Pathophysiological Mechanisms of Retinal Ganglion Cell Degeneration. Life 2022, 12, 638. [ Google Scholar] [ CrossRef] Passani, A.; Posarelli, C.; Sframeli, A.T.; Perciballi, L.; Pellegrini, M.; Guidi, G.; Figus, M. Cannabinoids in Glaucoma Patients: The Never-Ending Story. J. Clin. Med. 2020, 9, 3978. [ Google Scholar] [ CrossRef]

Murtagh, P.; O’Brien, C. Corneal Hysteresis, Intraocular Pressure, and Progression of Glaucoma: Time for a “Hyst-Oric” Change in Clinical Practice? J. Clin. Med. 2022, 11, 2895. [ Google Scholar] [ CrossRef] [ PubMed]

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Nocentini, A.; Supuran, C.T. Adrenergic agonists and antagonists as antiglaucoma agents: A literature and patent review (2013–2019). Expert Opin. Ther. Pat. 2019, 29, 805–815. [ Google Scholar] [ CrossRef] [ PubMed] Mori, A.; Ezawa, Y.; Asano, D.; Kanamori, T.; Morita, A.; Kashihara, T.; Sakamoto, K.; Nakahara, T. Resveratrol dilates arterioles and protects against N-methyl-d-aspartic acid-induced excitotoxicity in the rat retina. Neurosci. Lett. 2023, 793, 136999. [ Google Scholar] [ CrossRef] [ PubMed] The study has some potential limitations. First, it was conducted in one centre and the results may be different in different populations. Additionally, presence of relative afferent pupillary defect which may be helpful in indication was not included as inclusion criterion. The authors decided to include patients with clinically unilateral form of the disease. The follow-up of the included patients was not planned. That is why there is the possibility of misdiagnosing the patients with asymmetric NTG at presentation as unilateral disease. All patients from the group of young NTG patients were negative in MRI neuroimaging. However, the group may be too small to conclude and needs to be confirmed in the next studies. Fan N, Wang P, Tang L, Liu X. Ocular blood flow and normal tension glaucoma. Biomed Res Int. 2015;2015:308505. Vijayakumar A, Tiwari R, Kumar Prabhuswamy V: Thromboangiitis Obliterans (Buerger’s Disease)-Current Practices. Int J Inflam. 2013, 2013: 156905-156913.

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Definition of normal tension glaucoma

Fan, N.; Tan, J.; Liu, X. Is “normal tension glaucoma” glaucoma? Med. Hypotheses 2019, 133, 109405. [ Google Scholar] [ CrossRef] Collaborative Normal-Tension Glaucoma Study Group. The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am. J. Ophthalmol. 1998, 126, 498–505. [ Google Scholar] [ CrossRef] [ PubMed] The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2415/14/130/prepub Zhao, J.; Solano, M.M.; Oldenburg, C.E.; Liu, T.; Wang, Y.; Wang, N.; Lin, S.C. Prevalence of Normal-Tension Glaucoma in the Chinese Population: A Systematic Review and Meta-Analysis. Am. J. Ophthalmol. 2019, 199, 101–110. [ Google Scholar] [ CrossRef] As unilateral NTG was the most frequent indication for neuroimaging in our study, we looked into the clinical records of the patients with clinically significant results trying to find similarities. In some cases, the high discrepancy between the VF of the healthy and the affected eye was obvious, making it a possible criterion for further diagnostics. Additionally, the detailed evaluation of VF pattern showed that the morphology of these scotomas was not typical in the course of glaucoma. However, an almost similar group of patients, mainly with pituitary gland tumours, had no scotoma in the affected eye.

Investigators have reported an association between NTG, migraine and low systolic blood pressure, suggestingSakata, R.; Aihara, M.; Murata, H.; Saito, H.; Iwase, A.; Yasuda, N.; Araie, M. Intraocular pressure change over a habitual 24-hour period after changing posture or drinking water and related factors in normal tension glaucoma. Investig. Ophthalmol. Vis. Sci. 2013, 54, 5313–5320. [ Google Scholar] [ CrossRef] [ PubMed] Hassan, D.H.; Abdelmonem, R.; Abdellatif, M.M. Formulation and Characterization of Carvedilol Leciplex for Glaucoma Treatment: In-Vitro, Ex-Vivo and In-Vivo Study. Pharmaceutics 2018, 10, 197. [ Google Scholar] [ CrossRef] [ PubMed] The patient had normal IOP values in his diurnal IOP curve without treatment (maximum value, 18–20 mmHg), discarding higher IOPs measured out of office. The finding of ultrasound pachymetry was 515/520 μm, and the patient had normal IOP measured with a PASCAL tonometer, ruling out probable corneal biomechanical underestimations. The patient had a normal polysomnography study, excluding SAS, and normal macular and peripapillary angio-OCT findings were detected. Mehran, N.A.; Sinha, S.; Razeghinejad, R. New glaucoma medications: Latanoprostene bunod, netarsudil, and fixed combination netarsudil-latanoprost. Eye Lond. 2020, 34, 72–88. [ Google Scholar] [ CrossRef]