Herpatch Cold Sore Treatment Serum - Treat & Prevent Coldsores - Cold Sore Cream Alternative - Heals in 24 Hrs - Relieves Pain, Reduce Swelling & Blistering - Clinically Proven - inc SPF 30 Lip Balm.

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Carson, C. F., Ashton, L., Dry, L., Smith, D. W. & Riley, T. V. Melaleuca alternifolia (tea tree) oil gel (6%) for the treatment of recurrent herpes labialis. J. Antimicrob. Chemother. 48, 450–451 (2001). Herpes simplex labialis (HSL) is a worldwide infection of the oral and perioral regions caused by an infection with Herpes Simplex Virus type 1 (HSV-1) or, rarely, Herpes Simplex Virus type 2 (HSV-2). Despite the high prevalence of HSL, the disease has not yet been well characterized. The seroprevalence of HSV-1 in Germany was 78.4% from 2008 until 2011 1, 2. While many infections remain subclinical, other patients suffer from painful recurrent infections.

Darai, G., Handermann, M., Sonntag, H. G., Tidona, C. & Zöller, L. In Lexikon der Infektionskrankheiten des Menschen (Third Edition) (ed. Gholamreza Darai) 388–91 (Springer, 2009). Whenever I feel the first symptoms of itching on my lips I take a Herpatch. It’s like a miracle. It helps. I always have a couple of Herpatch ready in my handbag. Can’t live without them.Van Vloten, W. A., Swart, R. N. & Pot, F. Topical acyclovir therapy in patients with recurrent orofacial herpes simplex infections. J. Antimicrob. Chemother. 12, 89–93 (1983).

Besides the film-forming ingredients a number of other substances have been incorporated in Herpatch Cold Sore Serum : Beta-glukan, osim što oblikuje zaštitni sloj, smiruje, štiti i hidratizira kožu, što pomaže u zacjeljivanju rane; The statistical analysis of the reaction rate and the reaction quality showed statistically significant differences between Herpatch and Compeed as well as between Herpatch and Zovirax, both in favour of Herpatch. Karlsmark et al. evaluated the same parameters without assessing statistically significant differences between Compeed and Zovirax 22. Hydrocolloid wound dressings such as the Compeed patches promote re-epithelialization and reduce inflammatory responses 41, 42. However, in this clinical trial, the patch had to be removed several times due to the patch margins peeling off. This was caused particularly by liquids such as saliva, food or drinks or by facial expressions. The peeled-off margins led to discomfort and caused the patient to renew the patch. With every replacement, already formed crusts were torn off with the patch, causing pain while promoting primary wound healing. Accompanying symptoms such as pain, tingling, swelling, or burning were also assessed in comparable trials 43, 44. The duration and intensity of symptoms were rated and showed comparable distributions independent of the applied product. This evaluation is important to prove the effective impact of treatment on healing. Spruance, S. L. et al. High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies. Antimicrob. Agents Chemother. 47, 1072–1080 (2003).

Jautová, J. et al. Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage): Randomized, controlled double-blind study. Wien. Med. Wochenschr. 169, 193–201 (2019). Junker, J. P. E., Kamel, R. A., Caterson, E. J. & Eriksson, E. Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments. Adv. Wound Care 2, 348–356 (2013). An alternative is provided in the Compeed Invisible Cold Sore Patches that include no antiviral ingredient (Compeed; Johnson & Johnson Santé Beauté France SAS, Sézanne, France). The cytotoxicity was tested on fibroblasts. Further studies examined the irritation of the patches on rabbits and the sensitivity on guinea pigs. The outer layer of the patch consists of a semiocclusive polyurethane film, which allows excessive wound exudate to evaporate while keeping the lesion moist, ensuring an optimum moisture level. The patch seals the wound and arranges ideal conditions for wound healing. The patch functions as a shield, protecting surrounding areas from infection. As soon as the first symptoms occur, the patch is placed on the lesion, replaced if required, and worn for 24 hours until complete healing occurs 19.

To produce significant results, the sample size was estimated with the programme G*Power 3.1.9.2 23. A sample size of 180 patients (60 participants per treatment group) was calculated with a statistical power of 0.8, an alpha error of 0.05, and a 15% drop-out quote with an effect size of 0.5. All data were statistically analysed with the program SPSS 24.0. Malvy, D. et al. Epidemiology of orofacial herpes simplex virus infections in the general population in France: results of the HERPIMAX study. J. Eur. Acad. Dermatol. 21, 1398–1403 (2007). The course of disease in recurrent HSL generally involves several stages. Within the precursor stage, pain, tingling, or burning sensations in the affected area may occur. This is followed by the appearance of a macule, turning into a papule and leading to the formation of a vesicle. The vesicle bursts, and the formation of a soft scab is initiated. Subsequently, the soft scab is replaced by a hard scab. Over time, the scab falls off, and the lesion is fully healed without scarring 6, 7, 8. While healing, the process is often accompanied by symptoms such as pain, discomfort or reduced self-esteem 6. Complete healing takes seven to ten days 7. Senti, G. et al. A Randomized, Double-Blind, Placebo-Controlled Study to Test the Efficacy of Topical 2-Hydroxypropyl-Beta-Cyclodextrin in the Prophylaxis of Recurrent Herpes Labialis. Dermatology 226, 247–252 (2013). Gross, G. & Braun, D. Efficacy and tolerability of topical foscarnet sodium in treatment of herpes labialis: Results of post-marketing surveillance. Hautarzt 57, 40–46 (2006).Having suffered with cold sores since a child I just wanted to say thank you for this incredible treatment I have tried countless other products and this is by far the best I've ever come across. I now keep it permanently in the house and one in the car in case I feel one coming. Again thank you. As a sufferer of cold sores all year round this little tube is a life saver. Due to design of the tube (looks like a lip gloss once opened) it can be applied directly to the affected area. I made sure I gave it a good wipe after application though as I wouldn’t want to risk spreading to other areas of my mouth. Herpatch can be used at any stage of the outbreak. However, we suggest its application at the first sign of appearance. The primary endpoint examines the existence of differences between the three products in terms of healing time. The assessments of the reaction rate and the reaction quality by the clinician (CGAT) and by the subject (SGAT) were defined as the secondary endpoints. The analysis of the patient’s questionnaire was determined as the tertiary endpoint. Statistical analysis Subjects were excluded if they showed limited compliance, suffered from severe illnesses, or had taken antibiotics or anti-inflammatory drugs two weeks ahead of participation. Pregnant or breastfeeding females were excluded. Hypersensitivity against the ingredients contained in the products or alcohol or drug abuse were additional exclusion criteria. If the patient had already applied a product for the treatment of HSL on the present lesion or had participated in a different clinical study, the subject was not allowed to participate.