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Which Technique and Which Algorithm Should be Used for the Analysis of the ER Status in Breast Cancer? Errera M-H, Michaelides M, Keane PA, Restori M, Paques M, Moore AT, et al. The extended clinical phenotype of dome-shaped macula. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2014; 252(3):499-508

Saxena S, Srivastav K, Cheung CM, Ng JY, Lai TY. Photoreceptor inner segment ellipsoid band integrity on spectral domain optical coherence tomography. Clinical Ophthalmology. 2014; 8:2507-2522 Spectral domain optical coherence tomography (SD-OCT) scan with external retinal landmarks from a healthy subject. RPE: retina pigment epithelium; IZ: interdigitation zone; EZ: ellipsoid zone; and ELM: external limiting membrane. The double greater-than sign, >>, is used for an approximation of the much-greater-than sign ≫. ASCII does not have the much greater-than sign.Ohsugi H, Ikuno Y, Oshima K, Yamauchi T, Tabuchi H. Morphologic characteristics of macular complications of a dome-shaped macula determined by swept-source optical coherence tomography. American Journal of Ophthalmology. 2014; 158(1):162-170.e1 Itoh Y, Inoue M, Rii T, Hirota K, Hirakata A. Correlation between foveal cone outer segment tips line and visual recovery after epiretinal membrane surgery. Investigative Ophthalmology & Visual Science. 2013; 54(12):7302 You have pain, pressure, tightness, or other discomforts in both shoulders and both arms, even if you do not have chest pain A picture of a car with an orange glow coming from its means, that no vehicles carrying explosives are allowed in this area. A shoulder nerve injury, also called brachial plexopathy, is when damage occurs to a network of nerves in the front of the shoulder known as the brachial plexus. This damage can occur from injury, inflammation, radiation therapy, or other medical conditions. Symptoms include sharp pain in the shoulder, arm, or hand. Numbness or weakness in the shoulder or arm may also occur.

Interpretation of IHC results may be performed using a standardised assessment methodology such as the Allred or H-score. 6 Patient Selection The earliest known use of the symbols < and > is found in Artis Analyticae Praxis ad Aequationes Algebraicas Resolvendas ( The Analytical Arts Applied to Solving Algebraic Equations) by Thomas Harriot, published posthumously in 1631. [1] The text states " Signum majoritatis ut a>b significet a majorem quam b (The sign of majority a > b indicates that a is greater than b)" and " Signum minoritatis ut a < b significet a minorem quam b (The sign of minority a < b indicates that a is less than b)."Early Breast Cancer Trialists' Collaborative Group (EBCTCG) Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet 2011;378(9793):771-84. Triangular signs are warning signs, indicating a potential hazard or obstacle that requires extra attention from the driver. Treatment involves easing symptoms and improving the patient's quality of life through pain medications, exercise, improved diet, and help with managing stressful situations. Bolz M, Schmidt-Erfurth U, Deak G, Mylonas G, Kriechbaum K, Scholda C. Optical coherence tomographic hyperreflective foci. Ophthalmology. 2009; 116(5):914-920 ER is one of the most informative biomarkers in breast cancer. ER expression is capable of differentiating two fundamentally distinct tumour sub-types, with the majority of luminal breast tumours expressing ER. 2 Tumours that express ER are dependent on oestrogen supply for growth and survival and are generally well-differentiated, less aggressive, and have a better prognosis. ER expression occurs in over three-quarters of breast tumours and is more frequent in patients over 50 years old. 1,3 ER as a Prognostic Biomarker in Breast Cancer

Symptoms that never occur with repetitive strain injury of the shoulder ("swimmer's shoulder"): severe shoulder pain, shoulder injury Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N, et al. Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis. Progress in Retinal and Eye Research. 2015; 48:82-118 Soudier G, Gaudric A, Gualino V, Massin P, Nardin M, Tadayoni R, et al. Long-term evolution of dome-shaped macula: Increased macular bulge is associated with extended macular atrophy. Retina. 2016; 36(5):944-952 ER is an important prognostic biomarker in breast cancer. ER-positive tumours have a better prognosis than ER-negative tumours. Overall survival, disease free survival, recurrence/relapse-free survival, 5-year survival, time to treatment failure and time to recurrence have all been shown to be positively associated with ER expression. 4

Arevalo JF, Lasave AF, Arias J, Serrano M, Arevalo F. Clinical applications of optical coherence tomography in the posterior pole: The 2011 José Manuel Espino lecture—part I. Clinical Ophthalmology. 2013; 7:2165-2179 Sun JK, Radwan SH, Soliman AZ, Lammer J, Lin MM, Prager SG, et al. Neural retinal disorganization as a robust marker of visual acuity in current and resolved diabetic macular edema. Diabetes. 2015; 64(7):2560-2570 Symptoms that always occur with frozen shoulder (adhesive capsulitis of the shoulder): stiff shoulder The GP may prescribe medicine for your ear infection, depending on what's caused it. Infections inside the ear ER testing is recommended for all newly diagnosed invasive breast cancers and breast cancer recurrence and all patients with detectable ER expression, defined as ≥1% of invasive cancer cells, should be offered endocrine therapy. 4,6 References

Treatment usually begins with rest and over-the-counter, nonsteroidal anti-inflammatory pain relievers. Further care will be determined by medical providers once the exact cause of the pain has been determined. Senkus E, Kyriakides S, Penault-Llorca F, et al. Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013;24(Suppl 6):vi7-23. The condition can happen if an injury to the shoulder forces it to stay immobilized while healing. Additional risk factors may be diabetes, thyroid abnormalities, and heart disease.

A pharmacist can help with an ear infection

Fibromyalgia is a set of chronic symptoms that include ongoing fatigue, diffuse tenderness to touch, musculoskeletal pain, and usually some degree of depression. a long-term medical condition (such as diabetes or a heart, lung, kidney or neurological disease) and symptoms of an ear infection Schaal KB, Freund KB, Litts KM, Zhang Y, Messinger JD, Curcio CA. Outer retinal tubulation in advanced age-related macular degeneration: Optical coherence tomographic findings correspond to histology. Retina. 2015; 35(7):1339-1350 Grewal DS, O’Sullivan ML, Kron M, Jaffe GJ. Association of disorganization of retinal inner layers with visual acuity in eyes with uveitic cystoid macular edema. American Journal of Ophthalmology. 2017; 177:116-125

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