Outlive: The Science and Art of Longevity

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Tools of Titans is a deep dive into the lives, habits, and routines of world-renowned entrepreneurs, athletes, and leaders. It offers actionable advice from over 100 interviews designed to help the reader achieve success. The Emperor of All Maladies by Siddhartha Mukherjee For someone with a low level of fitness that might mean two 30-minute sessions a week. For Attia, it involves four weekly one-hour-long sessions cruising on his bike while listening to an audiobook. “A side benefit of zone 2 is that it helps with cognition by increasing cerebral blood flow and by stimulating the production of BDNF, brain-derived neurotrophic factor,” he explains, noting that for this reason it is an important part of Alzheimer’s disease prevention. What if … Peter Attia and Chris Hemsworth talk during the making of Limitless. Photograph: Craig Parry/National Geographic for Disney+ Peter Attia, MD, is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan. He is the host of The Drive, one of the most popular podcasts covering the topics of health and medicine. From 2001 to 2006, Attia specialized in surgical oncology at the Johns Hopkins Hospital in Baltimore, Maryland. [4] During this time, he also undertook research at the NIH in Bethesda, Maryland, focusing on cancer immunotherapy for melanoma. [5]

Dr. Peter Attia is an acclaimed physician, scientist, and health enthusiast who has become a highly respected figure in the healthcare industry. He is renowned for his deep knowledge of nutrition interventions that can promote health and longevity. His book recommendations have been sought by those eager to learn more about these topics.

When I ask Attia how much it costs to sign up for treatment at Early Medical, he sounds rather coy. “It varies – it’s not a fixed fee. It’s a little more in the first year and then the cost sort of ratchets down because we’re doing more work early on.” Dr Peter Attia walking near Austin, Texas. He practises archery and walks three miles every day. Photograph: Katie Hayes Luke/The Guardian If trauma dominated the nighttime, our days belonged to patients with vascular disease, GI disease, and especially cancer. The difference was that these patients’“wounds” were caused by slow-growing, long-undetected tumors, and not all of them survived either—not even the wealthy ones, the ones who were on top of the world. Cancer doesn’t care how rich you are. Or who your surgeon is, really. If it wants to find a way to kill you, it will. Ultimately, these slow deaths ended up bothering me even more.

One of his big themes is the kind of genetic screening that can alert people to their susceptibility to life-limiting conditions, so they can take risk-reducing action – something seen in the Hemsworth series, when the actor is confronted with the fact that he is carrying two copies of a gene that make him up to 10 times more likely than most other people to develop Alzheimer’s disease. Hemsworth later hinted that it had played some part in his recent decision to take a break from his profession.Husten, Larry. "A Manhattan Project To End The Obesity Epidemic". forbes.com . Retrieved 31 October 2018. Attia writes: “data comes from studies of… people who have lived to the age of one hundred and beyond, often in good health… many of them get to enjoy one, or two, or even three Bonus Decades…. Researchers… [found that] individuals [had] very little in common with one another genetically… Natural selection has endowed us with genes that work beautifully to help us develop, reproduce, and then raise our offspring [but] after the age of reproduction, natural selection loses much of its force… [Yet] a handful of potential longevity genes… are possibly relevant to our strategy. One [gene]… called … APOE (apolipoprotein E) that is involved in cholesterol transport and processing, and it has three variants: e2, e3, and e4… The e2 variant of APOE… seems to protect its carriers against dementia—and it also turns out to be very highly associated with longevity… FOXO3 belongs to a family of “transcription factors,” which regulate how other genes are expressed—meaning whether they are activated or “silenced.”… When FOXO3 is activated, it in turn activates genes that generally keep our cells healthier. It seems to play an important role in preventing cells from becoming cancerous as well.”