A.Vogel Venagel Horse Chestnut Gel | for The Relief of Tired, Aching Legs | 100ml

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Costa Santos D, Lérias G, Madruga I. Drug-induced Liver Injury Due to a Horse Chestnut Dietary Supplement. Eur J Case Rep Intern Med 2021;8(3):002389. View abstract. Horse chestnut extract typically contains 16–20% aescin. In most studies, the dosage used is 100–150 mg of aescin per day. Hence, potential toxic effects of higher doses are unknown. Therefore, it’s best to follow suggested dosing instructions ( 2, 30).

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HCSE administration increases sensitization to calcium ions, decreases the permeability of small vessels, and enhances venous contractile activity, thereby improving venous tone and having a “sealing effect” at the sight of injury. It is possible that aesculin, a hydroxycoumarin, may potentiate the effect of anticoagulant medications. However, other research suggests this effect is only seen with aesculin, a bark constituent not found in HCSE. Vayssairat, M., Debure, C., Maurel, A., and Gaitz, J. P. Horse-chestnut seed extract for chronic venous insufficiency. Lancet 4-27-1996;347(9009):1182. View abstract. As I have mentioned, one of the main causes of swelling is excessive salt, so you need to be mindful of how much you consume in your diet. To limit your chances of swollen ankles and feet it is best to pass on the table salt and look at a low-sodium alternative or reduced salt varieties of foods which are usually high in salt, such as soups, sauces, crisps and smoked meats. Try to avoid eating highly processed foods as these often have a high salt content.In rats, escin reduced arthritis in combination with a low dosage of prednisone (Deltasone, Rayos) [ 26]. https://www.ema.europa.eu/en/documents/herbal-monograph/draft-european-union-herbal-monograph-aesculus-hippocastanum-l-semen-revision-1_en.pdf Escin shouldn’t be confused with esculetin – the poisonous ingredient in non-processed horse chestnuts [ 4].

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Clinical testing of 3% horse chestnut gel on 40 female volunteers (3 times a day, 9 weeks) diminished wrinkles around the eyes compared to the controls [ 15]. Melegova, N., et al. (2022). Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma [Abstract]. If over-the-counter options aren't working, you may consider an alternative treatment. Here's what researchers say about essential oils for varicose… READ MORETakegoshi K, Tohyama T, Okuda K, et al. A case of Venoplant-induced hepatic injury. Gastroenterol Jpn 1986;21:62-5. View abstract. For these reasons, always consult with your healthcare provider before taking horse chestnut extract — especially if you have a medical condition or are currently taking medications. Ji H, Zhang G, Yue F, Zhou X. Adverse event due to a likely interaction between sodium aescinate and ginkgo biloba extract: a case report. J Clin Pharm Ther. 2017;42(2):237-238. doi: 10.1111/jcpt.12500. View abstract.

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It is native to the countries of the Balkan Peninsula, but because of its large, showy flower clusters, the tree is cultivated worldwide for its beauty. Flowers are white or pink with a small red spot.Ginger is a very potent spice that is great for relieving the symptoms of varicose veins and can even prevent blood clotting. 2. Drink plenty of water However, this ointment also contained other anti-inflammatory compounds, making it unclear whether aescin alone would have the same effects. In a study of 219 Chinese male patients with infertility (due to prostate vein swelling) 60 mg of escin for 2 months improved sperm quality, motility, and amount (by at least 30%) [ 14]. The anti-inflammatory properties of horse chestnut seed extract may help relieve symptoms of hemorrhoids by reducing inflammation and swelling in the affected veins ( 17).

A. Vogel Venagel Horse Chestnut Gel, 100g - VictoriaHealth

Guillaume, M. and Padioleau, F. Veinotonic effect, vascular protection, antiinflammatory and free radical scavenging properties of horse chestnut extract. Arzneimittelforschung 1994;44(1):25-35. View abstract. The result is decreased edema and swelling. Aescin’s anti-edematous property is also attributed in part to its inhibition of hypoxia and the resultant reduction of ATP content in endothelial cells. Popp W, Horak F, Jager S, et al. Horse chestnut (Aesculus hippocastanum) pollen: a frequent cause of allergic sensitization in urban children. Allergy 1992;47:380-3. View abstract.

A 2015 review article indicates that horse chestnut seed extract could provide a safe and tolerable treatment option for CVI. Similarly, the European Medicines Agency (EMA) highlights that the extract may relieve symptoms of discomfort and heaviness of the legs associated with CVI. Hemorrhoids Edem E, Kahyaoglu B, Çakar MA. Acute Effusive Pericarditis due to Horse Chestnut Consumption. Am J Case Rep. 2016;17:305-8. View abstract. Hawrelak JA, Wohlmuth H, Pattinson M, et al. Western herbal medicines in the treatment of irritable bowel syndrome: a systematic review and meta-analysis. Complementary Therapies in Medicine. 2020;48:102233.