Tempo Regular Menthol Tissues x 1

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Liu Z, Shen C, Tao Y, Wang S, Wei Z, Cao Y, et al. Chemopreventive efficacy of menthol on carcinogen-induced cutaneous carcinoma through inhibition of inflammation and oxidative stress in mice. Food Chem Toxicol. (2015) 82:12–8. doi: 10.1016/j.fct.2015.04.025 In various patches ranging from fever-reducing patches applied to children's foreheads to "foot patches" to relieve numerous ailments (the latter being much more frequent and elaborate in Asia, especially Japan: some varieties use "functional protrusions", or small bumps to massage one's feet as well as soothing them and cooling them down). Essential oils are derived from plants. Their purpose is not exactly known, but some experts think that it could be a protective mechanism for the plant; others propose that they might attract pollinators. Peppermint is a popular essential oil used alone and in combination with other essential oils. Menthol is the main component of peppermint oil and is responsible for the noticeable cooling sensation. Menthol is extracted from plants or synthesized and can be found in throat lozenges, intranasal inhalers, lotions, pain creams, foods, and many other products. Objective: Sepsis-induced acute lung injury (ALI) and acute kidney injury (AKI) are major causes of mortality. Menthol is a natural compound that has anti-inflammatory and antioxidative actions. Since exaggerated inflammatory and oxidative stress are characteristics of sepsis, the aim of this study was to evaluate the effect of menthol against sepsis-induced mortality, ALI, and AKI.

TRPM8 receptor and menthol in pain management - ScienceDirect TRPM8 receptor and menthol in pain management - ScienceDirect

Overall: love the products, I have just right conditions to use them under and I definitely will buy again when one of the family is ill.I moved over to these after the man size as I was very stuffy. The smell isn't too strong nor do you get that burning menthol sensation. I cannot smell anything currently so perhaps they could have been a tad whiffier. In perfumery, menthol is used to prepare menthyl esters to emphasize floral notes (especially rose).

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Paraffin-embedded sections of the lung and kidney specimens were processed for the immunohistochemical study ( 45). Immunohistochemical staining was carried out for cleaved caspase-3, B-cell lymphoma 2 (Bcl-2) protein, proliferating cell nuclear antigen (PCNA), and TNF-α using rabbit monoclonal anti-caspase-3 (catalog number ab32042, Abcam, Cambridge, United Kingdom), rabbit polyclonal anti-Bcl-2 (catalog number ab194583, Abcam, Cambridge, United Kingdom), mouse monoclonal anti-PCNA (catalog number ab29, Abcam, Cambridge, United Kingdom), and rabbit monoclonal anti-TNF-α (catalog number EPR21753-109, Abcam, Cambridge, United Kingdom), respectively. To ensure the specificity of the antibody reaction, a control experiment was performed following the same steps, but without the addition of the primary antibody. Positive controls samples were human vascular endothelial cells for caspase-3, human lung cancer for Bcl-2, liver tissue for PCNA, and rat splenocytes for TNF-α. Image Capture Abdel-Daim MM, Mahmoud OM, Al Badawi MH, Alghamdi J, Alkahtani S, Salem NA. Protective effects of Citrus limonia oil against cisplatin-induced nephrotoxicity. Environ Sci Pollut Res Int. (2020) 27:41540–50. doi: 10.1007/s11356-020-10066-x Ten random non-overlapping fields for each slide from each group from lung and kidney tissues were selected and imaged using power X400 ( 46, 47). The mean surface area fraction of anti-cleaved caspase-3, PCNA, Bcl2, and TNF-α immuno-positive cells were measured using ImageJ software (version 1.51k, Wayne Rasband, National Institutes of Health, United States) for image analysis. Statistical Analysis Lee I, Hüttemann M. Energy crisis: the role of oxidative phosphorylation in acute inflammation and sepsis. Biochim Biophys Acta. (2014) 1842:1579–86. doi: 10.1016/j.bbadis.2014.05.031 In organic chemistry, menthol is used as a chiral auxiliary in asymmetric synthesis. For example, sulfinate esters made from sulfinyl chlorides and menthol can be used to make enantiomerically pure sulfoxides by reaction with organolithium reagents or Grignard reagents. Menthol reacts with chiral carboxylic acids to give diastereomic menthyl esters, which are useful for chiral resolution.Case 1. A mother called Poison Control because an older child poured peppermint oil on her 3-month-old baby's head. She thought that it likely got into the baby's eyes and maybe into the mouth as well. The baby was not opening his eyes, the skin looked irritated and red, and the baby was crying. Poison Control recommended washing the baby's skin with soap and water, gently irrigating the eyes with water, and giving the baby something to drink, either by nursing or by giving formula.

Menthol Have Harmful Effects? | Poison Control Can Menthol Have Harmful Effects? | Poison Control

Oppenheim, A. (1862). "On the camphor of peppermint". J. Chem. Soc. 15: 24. doi: 10.1039/JS8621500024. As a naturally occurring cyclic monoterpene, menthol may utilize its chemical structure (e.g., hydroxyl groups) for its potent antioxidant effects. Several previous studies have concluded that the major monoterpenoids, particularly menthol, are responsible for the majority of the mint’s antioxidant activity ( 11, 12). In general, phytochemicals exert their antioxidant effects by scavenging free radicals, chelating divalent metals, donating hydrogen or electrons, and facilitating the decomposition of peroxyl radicals. As a result, phytochemicals can inhibit the formation of free radicals, slow or inhibit the autoxidation process (chain-breaking antioxidant), or accelerate the termination of autoxidation. Wu et al. ( 12) use in vitro chemical- and cell-based assays and in vivo tests with C. elegans model to prove that the major monoterpenoids of mint essential oil, particularly menthol, have potent antioxidant effects. Biological activity of menthol: receptor activity and signaling pathways The animal study was reviewed and approved by the Commission on the Ethics of Scientific Research, Faculty of Pharmacy, Minia University (Approval Number: ES02/2020). Author ContributionsTo evaluate kidney function, the serum creatinine level was measured in all groups. Induction of sepsis by the CLP procedure significantly ( p< 0.05) increased the serum creatinine level compared with the sham group, while menthol treatment after CLP surgery significantly ( p< 0.05) abolished this increase ( Figure 3C). Menthol Reduces Oxidative and Improves Antioxidant Activity in Lung and Kidney Tissues of Septic Animals Hiki, N.; Kaminishi, M.; Hasunuma, T.; Nakamura, M.; Nomura, S.; Yahagi, N.; Tajiri, H.; Suzuki, H. (2011). "A Phase I Study Evaluating Tolerability, Pharmacokinetics, and Preliminary Efficacy of L-Menthol in Upper Gastrointestinal Endoscopy". Clin. Pharmacol. Ther. 90 (2): 221–228. doi: 10.1038/clpt.2011.110. PMID 21544078. S2CID 24399887.