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This higher solubility has led to suggestions that creatine HCL is more easily absorbed by the intestines and therefore a lower dose can be taken vs. creatine monohydrate. Sahlin K, Harris RC. The creatine kinase reaction: a simple reaction with functional complexity. Amino Acids. 2011;40(5):1363–7.
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Easton C, et al. The effects of a novel “fluid loading” strategy on cardiovascular and haematological responses to orthostatic stress. Eur J Appl Physiol. 2009;105(6):899–908.Allah Yar R, Akbar A, Iqbal F. Creatine monohydrate supplementation for 10 weeks mediates neuroprotection and improves learning/memory following neonatal hypoxia ischemia encephalopathy in female albino mice. Brain Res. 2015;1595:92–100. Canete S, et al. Does creatine supplementation improve functional capacity in elderly women? J Strength Cond Res. 2006;20(1):22–8. If proper precautions and supervision are provided, creatine monohydrate supplementation in children and adolescent athletes is acceptable and may provide a nutritional alternative with a favorable safety profile to potentially dangerous anabolic androgenic drugs. However, we recommend that creatine supplementation only be considered for use by younger athletes who: a.) are involved in serious/competitive supervised training; b.) are consuming a well-balanced and performance enhancing diet; c.) are knowledgeable about appropriate use of creatine; and d.) do not exceed recommended dosages. Casey A, et al. Supplement use by UK-based British army soldiers in training. Br J Nutr. 2014;112(7):1175–84. Polyviou TP, et al. Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists. J Int Soc Sports Nutr. 2012;9(1):29.
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Andreassen OA, et al. Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington’s disease. Neurobiol Dis. 2001;8(3):479–91.Galvan E, et al. Acute and chronic safety and efficacy of dose dependent creatine nitrate supplementation and exercise performance. J Int Soc Sports Nutr. 2016;13:12. Sipila I, et al. Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina. N Engl J Med. 1981;304(15):867–70.
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Kreider RB, et al. Effects of serum creatine supplementation on muscle creatine content. J Exerc Physiologyonline. 2003;6(4):24–33. Edgar G, Shiver HE. The equilibrium between creatine and creatinine, in aqueous solution: the effect of hydrogen ion. J Am Chem Soc. 1925;47:1179–88.Thorsteinsdottir B, Grande JP, Garovic VD. Acute renal failure in a young weight lifter taking multiple food supplements, including creatine monohydrate. J Ren Nutr. 2006;16(4):341–5. Creatine monohydrate is the most effective ergogenic nutritional supplement currently available to athletes with the intent of increasing high-intensity exercise capacity and lean body mass during training. Candow DG. Sarcopenia: current theories and the potential beneficial effect of creatine application strategies. Biogerontology. 2011;12(4):273–81. Food supplements are not intended to replace a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended usage. Keep out of reach of children.