Hyaluronic Acid Serum for Skin- Anti-Aging, Serum Intense Hydration + Moisture, Non-greasy, Paraben-free-Best Hyaluronic Acid for Your Face (Pro Formula) 2oz

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Altman RD. Intra-articular sodium hyaluronate in osteoarthritis of the knee. Semin Arthritis Rheum 2000;30(2 Suppl 1):11-8. View abstract. Belalcázar-Rey S, Sánchez Huerta V, Ochoa-Tabares JC, et al. Efficacy and safety of sodium hyaluronate/chondroitin sulfate preservative-free ophthalmic solution in the treatment of dry eye: A clinical trial. Curr Eye Res. 2020:1-11. View abstract. Hashem AS, Issrani R, Elsayed TEE, Prabhu N. Topical hyaluronic acid in the management of oral lichen planus: A comparative study. J Investig Clin Dent 2019;10(2):e12385. View abstract. Our 5ml sachets contain a potent 17mg of pure fermentation-based mid-molecular weight hyaluronic acid, carefully complemented with 12mg (15% RDI) of vitamin C. This dynamic duo works harmoniously to replenish your body’s natural supply. As a naturally-occurring substance, hyaluronic acid is renowned for its safety and ease of integration into your daily life, becoming an ally in your quest for lasting beauty. SUITABLE FOR Dermatologists generally love CeraVe. Both Dr. Salyards and Dr. Brauer give CeraVe hyaluronic acid serum glowing recommendations for its effective but thoughtful formula. “You can’t go wrong with CeraVe products,” says Dr. Salyards, adding that they’re affordable, accessible, and suitable for those with sensitive skin and other skin issues that can make it harder to find the right skin care routine.

Baker, C. L., Jr. and Ferguson, C. M. Future treatment of osteoarthritis. Orthopedics 2005;28(2 Suppl):s227-s234. View abstract. While not a requirement, multiple types of hyaluronic acid certainly make a serum stand out from the fierce competition. Tula 24-7 Ultra Hydration serum contains three molecular weights of the humectant douse skin with hydration. We love a hyaluronic acid serum with low molecular weight in particular since it’s the most effective type at hydrating those deeper layers of skin.

The best hyaluronic acid serums to buy

Origoni M, Cimmino C, Carminati G, et al. Postmenopausal vulvovaginal atrophy (VVA) is positively improved by topical hyaluronic acid application. A prospective, observational study. Eur Rev Med Pharmacol Sci. 2016;20(20):4190-4195. View abstract. With 1.5% hyaluronic acid as the only active ingredient, Kiehl’s Ultra Pure High-Potency 1.5% hyaluronic acid serum is a simple but targeted formula. “I like Kiehl's, and this product has a potent formulation of hyaluronic acid, which is great,” Dr. Salyards says. With 1.5% concentration, it’s right in the range our dermatologists recommend—0.5 to 2.0 percent.

Delia P, Sansotta G, Pontoriero A, et al. Clinical Evaluation of Low-Molecular-Weight Hyaluronic Acid-Based Treatment on Onset of Acute Side Effects in Women Receiving Adjuvant Radiotherapy after Cervical Surgery: A Randomized Clinical Trial. Oncol Res Treat. 2019;42(4):217-223. View abstract. We spent over 432 hours testing hyaluronic acid serums, and in the end Isdinceutics Hyaluronic Concentrate was the clear winner. The serum left our skin feeling and looking glowy and even reduced the appearance and frequency of acne breakouts. We’ll keep our list updated as we test new products, so watch this space. According to dermatologists, hyaluronic acid is a gentle active ingredient that can be paired with many other active ingredients. You can use hyaluronic acid in the same routine as ingredients like retinol, vitamin C, and others. However, you should try to avoid layering multiple products that each contain hyaluronic acid. In doing so, you could cause some irritation from using too much of the same ingredient. Nava Greenfield, MD, is a board-certified dermatologist at Schweiger Dermatology Group in Brooklyn, NY. Greenfield is a member of the American Academy of Dermatology, the Women’s Dermatologic Society, and the American Medical Association.

Laurent, T. C., Dahl, I. M., Dahl, L. B., Engstrom-Laurent, A., Eriksson, S., Fraser, J. R., Granath, K. A., Laurent, C., Laurent, U. B., Lilja, K., and . The catabolic fate of hyaluronic acid. Connect.Tissue Res 1986;15(1-2):33-41. View abstract. Bardellini E, Amadori F, Schumacher RF, D'Ippolito C, Porta F, Majorana A. Efficacy of a solution composed by verbascoside, polyvinylpyrrolidone (PVP) and sodium hyaluronate in the treatment of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2016;38(7):559-62. View abstract. Torretta S, Marchisio P, Rinaldi V, et al. Topical administration of hyaluronic acid in children with recurrent or chronic middle ear inflammations. Int J Immunopathol Pharmacol. 2016;29(3):438-42. Ocak E, Mulazimoglu S, Kocaoz D, Mirici E, Dagli E, Acar A. Effect of adjunctive sodium hyaluronate versus surfactant nasal irrigation on mucociliary clearance in allergic rhinitis: a single-blind, randomised, controlled study. J Laryngol Otol 2021;135(6):529-532. View abstract. Savietto E, Marioni G, Maculan P, et al. Effectiveness of micronized nasal irrigations with hyaluronic acid/isotonic saline solution in non-polipoid chronic rhinosinusitis: A prospective, randomized, double-blind, controlled study. Am J Otolaryngol. 2020;41(4):102502. View abstract.

Overall Look: We took note of how each product worked over the course of the testing period, and whether or not our complexion looked better with regular use. We also noted any issues we had with product fragrance and how the serums interacted with sensitive skin. The serum contains fragrance, and although we found the scent calming and not at all overpowering, it could be irritating to very sensitive skin. Cagnacci A, Barattini DF, Casolati E, Pecoroni A, Mangrella M, Patrascu LC. Polycarbophil vaginal moisturizing gel versus hyaluronic acid gel in women affected by vaginal dryness in late menopausal transition: A prospective randomized trial. Eur J Obstet Gynecol Reprod Biol 2022;270:239-45. View abstract. John HE, Price RD. Perspectives in the selection of hyaluronic acid fillers for facial wrinkles and aging skin. Patient Prefer Adherence. 2009;3:225-230. doi:10.2147/ppa.s3183Percival SP. Complications from use of sodium hyaluronate (Healonid) in anterior segment surgery. Br J Ophthalmol 1982;66:714-6. View abstract. Goddard JC, Janssen DAW. Intravesical hyaluronic acid and chondroitin sulfate for recurrent urinary tract infections: systematic review and meta-analysis. Int Urogynecol J. 2018 Jul;29(7):933-942. Epub 2017 Nov 27. Review. View abstract. Formulated with mature skin in mind, Dr. Dennis Gross’s Hyaluronic Marine Booster contains moisturizing watermelon extract and centella asiatica (aka cica) to smooth the appearance of fine lines. We like that this multifunctional serum can be applied all over the face or on dry patches as needed. Do note that the water-like consistency is runny, so consider using the dropper applicator to dispense the product directly on the skin to avoid waste.

If you’re in the market for something that helps tone down redness, look to the Kiehl’s Ultra Pure High-Potency Hyaluronic Acid Serum. It’s made with only seven ingredients and is designed to calm, soothe, and replenish the skin. During testing, we found it to be incredibly effective—we actually could tell a difference in the appearance and feel of our skin on days when we used it vs. the days we didn’t use it. Our skin appeared healthier and younger; wrinkles and fine lines were less obvious and the overall feel of our skin was supple, smooth, and super-soft. While we didn’t experience any pilling or peeling under makeup, some say the product can do so. We recommend giving the product at least five minutes to absorb before layering on the rest of your skincare and makeup regimen.

Pellegatta G, Mangiavillano B, Semeraro R, et al. The effect of hyaluronic acid and chondroitin sulphate-based medical device combined with acid suppression in the treatment of atypical symptoms in gastroesophageal reflux disease. J Clin Med 2022;11(7):1890. View abstract. Alcohol can be added to skincare to preserve or stabilize the formula. Greenfield recommends avoiding it as much as you can, explaining that formulas with alcohol “can end up drying out your skin rather than hydrating it.” We love the Paula's Choice Hyaluronic Acid Booster with Ceramides, which is not only alcohol-free, but contains a blend ceramides to enhance the formula’s soothing nature. Additional Ingredients Nelson FR, Zvirbulis RA, Zonca B, et al. The effects of an oral preparation containing hyaluronic acid (Oralvisc) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. Rheumatol Int. 2015;35(1):43-52. View abstract.