skyn ICELAND Dissolving Microneedle Eye Patches with Hyaluronic Acid & Peptides: to Hydrate, Firm and Smooth Fine Lines (1 Pack)

Product Information

Vice Reversa currently have two products: Pimple Patches and Plumping Patches, containing active ingredients targeted for treating acne and decreasing fine lines and wrinkles, respectively. Vice Reversa Pimple Patches

Tucak,A.; Sirbubalo,M.; Hindija,L.; Rahić,O.; Hadžiabdić,J.; Muhamedagić,K.; Čekić,A.; Vranić,E. Micromachines 2020, 11, 961. doi:10.3390/mi11110961 Prausnitz, M. R.; Jiang, J.; Patel, S. R.; Gill, H. S.; Ghate, D.; McCarey, B. E.; Geroski, D. H.; Edelhauser, H. F. Invest. Ophthalmol. Visual Sci. 2007, 48, 3191. Acetyl hexapeptide-8 (also known as Argireline): it’s a section of Botox, which could potentially relax wrinkles slightly Datta,D.; Roy,G.; Garg,P.; Venuganti,V.V.K. J.DrugDeliverySci.Technol. 2022, 70, 103211. doi:10.1016/j.jddst.2022.103211

Peace Out Wrinkles, £25 | Peace Out

Castañeda,P.S.; Escobar-Chávez,J.J.; Vázquez,J.A.; Cruz,I.M.R.; Contreras,L.M.M. Iran.J.Pharm.Res. 2020, 19, 127–133. doi:10.22037/ijpr.2019.1100914 Making sure your hands are dry, take the patches out of the protective case and remove them from the protective film. Make sure you don’t touch the microneedles in the middle of the patch, since they can break. I was really surprised when I saw the two photos side by side – while the results were obvious to me (the nasty pressure from the pimple was completely gone), I didn’t expect to see such a huge difference on camera! In traditional microneedling, needle size is a major factor factor in the treatment’s effectiveness. Most people require needles that are 1.0mm or longer to reach the dermis. Methods of drug-loading depend on the type and construction of the manufactured microneedles, as well as the applied material. The properties of the drug must be carefully taken into consideration, as some active ingredients may decompose at higher temperatures or upon irradiation. In the case of solid microneedles prepared with the use of porous ceramic materials, the pores in the carrier material can be filled with the active ingredient in liquid or solid form. In the first case, the drug diffuses from the solution in the microneedle pores upon application. In the other case, the drug solution is loaded to the microneedles and in the next step the formulation is dried and the drug precipitates inside the pores. Upon application, the drug dissolves in a physiological fluid and, in this form, can permeate to the deeper tissues [161]. In the techniques involving polymers applied to obtain solid microneedles, the drug may be dissolved [162,163] or suspended [164] in the polymer or monomer solution. In the manufacturing of more complex systems, with the active ingredient incorporated in a specific compartment of a microneedle, more complex procedures involving both drug-loaded and drug-free solutions may be employed [165]. Hollow microneedles containing an empty canal inside are usually filled with active ingredient solution, either passively or with the use of pressure-driven methods [161]. In the systems using passive diffusion, the drug solution can be loaded to the canals inside the microneedles [141] or to an external compartment [166]. In pressure-driven systems, a reservoir with different pumping mechanisms is attached to the microneedle systems. Usually, manually operated syringes are reported [167,168], as well as micropumps [169] or actuator-equipped devices designed for self-injection [170].

Abdelkader,H.; Wertheim,D.; Pierscionek,B.; Alany,R.G. Pharmaceutics 2020, 12, 1158. doi:10.3390/pharmaceutics12121158

Before & After - Crow's Feet

Another well-known method is photolithography. In this technique, a silicon wafer is covered with a photosensitive or photoresistant polymer. The plate is then exposed to UV radiation. A pattern is formed depending on the coverage of the photosensitive or photoresistant layer. The wafer is then etched. A distinction can be made between wet and dry etching. The wet etching process uses a potassium hydroxide solution, while dry etching includes the physical methods ion milling and sputtering and the chemical method high-pressure plasma [156]. Lithographic techniques can be also used to prepare molds for the micromolding method. Micromolding, also known as solvent casting, is quite popular due to cost-effectiveness and simplicity. This method uses a mold usually made of silicone. The prepared mold is filled with a polymer solution or mixture. Then, air voids are removed with a centrifuge or through vacuum and the mold is baked in the oven. After cooling down, the finished microneedles are removed from the matrix [151,156,157]. This type of method is chosen to obtain microneedles for ophthalmic use [158-160]. Vision impairment and blindness https://www.who.int/news-room/fact-sheets/detail/blindness-and-visual-impairment (accessed Jul 19, 2022). In a subsequent work, the authors presented two types of patches for the delivery of triamcinolone acetonide (TA), a model steroidal drug applied in numerous inflammatory conditions to the posterior segment of the eye. A microneedle scleral patch (MSP) and a microneedle corneal patch (MCP) were obtained by micromolding with the use of PVP. The ex vivo experiments performed on porcine eye globe showed that, in comparison to MCP and TA nanosuspension, MSP yielded much greater TA concentrations in the vitreous humor and choroid-retinal complex after 5 min of application. Moreover, the patches were tested with a rabbit eye model. In this case, after 24 h, significantly higher TA accumulation was observed for MSP in comparison to MCP and intravitreal injection [175]. drug containing tip after optimization was delivered to the mouse cornea and efficiently reduced progression of keratitis Grumezescu,A.M. Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology; William Andrew, 2017.

Pascolini,D.; Mariotti,S.P. Br.J.Ophthalmol. 2012, 96, 614–618. doi:10.1136/bjophthalmol-2011-300539Kim,S.J.; Flach,A.J.; Jampol,L.M. Surv.Ophthalmol. 2010, 55, 108–133. doi:10.1016/j.survophthal.2009.07.005

Shi,H.; Zhou,J.; Wang,Y.; Zhu,Y.; Lin,D.; Lei,L.; Vakal,S.; Wang,J.; Li,X. Small 2022, 18, 2104657. doi:10.1002/smll.202104657 Chen,W.; Wang,C.; Yan,L.; Huang,L.; Zhu,X.; Chen,B.; Sant,H.J.; Niu,X.; Zhu,G.; Yu,K.N.; Roy,V.A.L.; Gale,B.K.; Chen,X. J.Mater.Chem.B 2014, 2, 1699–1705. doi:10.1039/c3tb21698e Rodgers,A.M.; Cordeiro,A.S.; Donnelly,R.F. Med.Devices:EvidenceRes. 2019, 12, 379–398. doi:10.2147/mder.s198220 What makes these patches better than microneedle patches from other brands? Our Dissolving Microneedle Eye Patches contain 1,100+ microneedles per patch. Other brands contain between 79 – 450 microneedles per patch, at most. This means that our patches deliver more than double the amount of active ingredients into the skin. Martanto,W.; Davis,S.P.; Holiday,N.R.; Wang,J.; Gill,H.S.; Prausnitz,M.R. Pharm.Res. 2004, 21, 947–952. doi:10.1023/b:pham.0000029282.44140.2eRoy,G.; Galigama,R.D.; Thorat,V.S.; Garg,P.; Venuganti,V.V.K. DrugDev.Ind.Pharm. 2020, 46, 1114–1122. doi:10.1080/03639045.2020.1776317 Thakur Singh, R. R.; Tekko, I.; McAvoy, K.; McMillan, H.; Jones, D.; Donnelly, R. F. Expert Opin. Drug Delivery 2017, 14, 525–537. doi:10.1080/17425247.2016.1218460 Microneedling is the process of inserting very fine, short needles into the skin to renew the surface by increasing cell turnover and releasing proteins. The procedure has been around since the mid-90s and usually takes place at a dermatologist’s office. Many dermatologists use a roller device or a pen-shaped automated microneedling device, both of which contain micro-fine needles ranging in diameter from 0.5 and 2.5 mm. There are also at-home versions, or dermarollers, typically made with microneedles that measure between 0.2 and 1 mm. Acetyl Hexapeptide-8 This age-fighting peptide has a relaxing effect on the look of fine lines around the eyes that can help delay the onset of deep creases.