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PubMed: Crocin prevents retinal ischaemia/reperfusion injury-induced apoptosis in retinal ganglion cells through the PI3K/AKT signalling pathway.
PubMed: Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form. PubMed: Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen.PubMed: Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells. In a 2008 animal study, a cream with saffron extract improved wound healing in mice. It increased the growth of skin cells, which is necessary to close wounds. The researchers credited this effect to the antioxidant and anti-inflammatory properties of saffron. Saffron flower petals look like thin, red threads. Soak a few threads in hot water to make saffron tea, or mix the liquid into savory dishes for flavor. And be prepared for the price — it’s one of the most expensive spices in the world. Inflammation, which can be caused by oxidative stress, is the root of many diseases. This includes inflammatory conditions involving the skin.
PubMed: Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity. PubMed: Saffron supplement maintains morphology and function after exposure to damaging light in mammalian retina. PubMed: Radical scavenging activity and LC-MS metabolic profiling of petals, stamens, and flowers of Crocus sativus L. Czerwony explains recent research on this reddish flower, sharing how saffron could have several health benefits. Health benefits of saffron In many studies, saffron was shown to improve the conditions of rats with cancet possibly as a result of the high concentration of antioxidant carotenoids. The crocin present in saffron might also help prevent other conditions such as breast cancer and leukemia; however, more research needs to be done in this area.Safranal gives saffron its distinct taste and aroma. Research shows that it may help improve your mood, memory, and learning ability, as well as protect your brain cells against oxidative stress ( 4).
A study in the Journal of Behavioral and Brain Science found that a saffron extract increased dopamine levels in the brain without changing the levels of other brain hormones, such as serotonin. PubMed: Inhibitory effects of aqueous crude extract of Saffron (Crocus sativus L.) on chemical-induced genotoxicity in mice. PubMed: Promotion of the growth of Crocus sativus cells and the production of crocin by rare earth elements. Saffron oil also provides many benefits for the skin, including lightening dark spots, giving your skin a healthy glow, reducing the appearance of acne or other blemishes, improving the texture of your skin, moisturizing your skin, and reducing the appearance of any scars that might be present.
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Saffron extract is said be very beneficial for treating depression and to reduce stress. It is also good for enhancing your mood. This oil is used as an aphrodisiac as well. Those who suffer from Alzheimer’s also benefit a lot by consuming saffron oil regularly. In today’s busy lifestyle, majority of the people are stressed and suffer from various problems, particularly insomnia. Saffron oil is a good remedy for treating insomnia and to get a good sleep. May improve memory in adults with Alzheimer’s disease. Saffron’s antioxidant properties may improve cognition in adults with Alzheimer’s disease ( 29). PubMed: An evidence-based systematic review of saffron (Crocus sativus) by the Natural Standard Research Collaboration. Saffron is used as an anticonvulsant (anti-seizure) remedy in Iranian folk medicine. Some studies in biologic models show that it can shorten some types of seizures. However, says Czerwony, we need larger clinical trials to find out more about how it works. PubMed: Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety.
PubMed: Effective isolation protocol for secondary metabolites from saffron: semi-preparative scale preparation of crocin-1 and trans-crocetin.PubMed: Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial. In small doses, saffron has a subtle taste and aroma and pairs well with savory dishes, such as paella, risottos, and other rice dishes. PubMed: Relaxant effect of Crocus sativus (saffron) on guinea-pig tracheal chains and its possible mechanisms. PubMed: Isolation of a CENTRORADIALIS/TERMINAL FLOWER1 homolog in saffron (Crocus sativus L.): characterization and expression analysis. PubMed: Study on diuretic activity of saffron (stigma of Crocus sativus L.) Aqueous extract in rat.
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