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Tissues and Issues

Tissues and Issues

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Localized scleroderma is confined to the skin and, sometimes, the muscle beneath it. Systemic sclerosis also involves the blood vessels and major organs. Coelho, N. M. & McCulloch, C. A. Contribution of collagen adhesion receptors to tissue fibrosis. Cell Tissue Res. 365, 521–538 (2016). Ogawa, S. et al. Relationship between liver tissue stiffness and histopathological findings analyzed by shear wave elastography and compression testing in rats with non-alcoholic steatohepatitis. J. Med. Ultrason. 43, 355–360 (2016). Xie, J. et al. Substrate elasticity regulates adipose-derived stromal cell differentiation towards osteogenesis and adipogenesis through β-catenin transduction. Acta Biomater. 79, 83–95 (2018).

Nonkeratinized stratified squamous epithelium – found in regions subject to abrasion, for example oral mucosa and vaginal lining Rapid and strong contraction; large, cylindrical, elongated cells; syncytium; peripheral and ovoid nuclei; striated; present in voluntary skeletal muscles Benech, J. C. et al. Diabetes increases stiffness of live cardiomyocytes measured by atomic force microscopy nanoindentation. Am. J. Physiol. Physiol. 307, C910–C919 (2014). Yanez, L. Z., Han, J., Behr, B. B., Pera, R. A. R. & Camarillo, D. B. Human oocyte developmental potential is predicted by mechanical properties within hours after fertilization. Nat. Commun. 7, 10809 (2016). Eby, S. F. et al. Shear wave elastography of passive skeletal muscle stiffness: influences of sex and age throughout adulthood. Clin. Biomech. 30, 22–27 (2015).

Zhang, G. et al. Development of tendon structure and function: regulation of collagen fibrillogenesis. J. Musculoskelet. Neuronal Interact. 5, 5–21 (2005). Delivery of land-based activities at Lupton house in partnership with the apricot centre costs of gardening tools. Structure: soma (cell body), axons (transmit impulses away from soma), dendrites (transmit incoming impulses) Jardeleza, M. S. R., Daly, M. K., Kaufman, J. D., Klapperich, C. & Legutko, P. A. Effect of trypan blue staining on the elastic modulus of anterior lens capsules of diabetic and nondiabetic patients. J. Cataract Refract. Surg. 35, 318–323 (2009).

Kaushik, G., Fuhrmann, A., Cammarato, A. & Engler, A. J. In situ mechanical analysis of myofibrillar perturbation and aging on soft, bilayered Drosophila myocardium. Biophys. J. 101, 2629–2637 (2011). Last, J. A., Thomasy, S. M., Croasdale, C. R., Russell, P. & Murphy, C. J. Compliance profile of the human cornea as measured by atomic force microscopy. Micron 43, 1293–1298 (2012). Ryan, A. J. & O’Brien, F. J. Insoluble elastin reduces collagen scaffold stiffness, improves viscoelastic properties, and induces a contractile phenotype in smooth muscle cells. Biomaterials 73, 296–307 (2015). Pawluś, A. et al. Shear wave elastography of the spleen: evaluation of spleen stiffness in healthy volunteers. Abdom. Radiol. 41, 2169–2174 (2016).

Chen, T., Bakhshi, H., Liu, L., Ji, J. & Agarwal, S. Combining 3D printing with electrospinning for rapid response and enhanced designability of hydrogel actuators. Adv. Funct. Mater. 28, 1800514 (2018). Speirs, D. C. D., de Souza Neto, E. A. & Perić, D. An approach to the mechanical constitutive modelling of arterial tissue based on homogenization and optimization. J. Biomech. 41, 2673–2680 (2008). Deringer, V. L., Caro, M. A. & Csányi, G. Machine learning interatomic potentials as emerging tools for materials science. Adv. Mater. 31, 1902765 (2019). Samir, A. E. et al. Shear wave elastography in chronic kidney disease: a pilot experience in native kidneys. BMC Nephrol. 16, 119 (2015).



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