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Vitamins A and C can also help to naturally brighten your skin’s appearance and promote a natural glow. Fibach, E.; Tan, E.-S.; Jamuar, S.; Ng, I.; Amer, J.; Rachmilewitz, E.A. Amelioration of oxidative stress in red blood cells from patients with β-thalassemia major and intermedia and E-β-thalassemia following administration of a fermented papaya preparation. Phytother. Res. 2010, 24, 1334–1338. [ Google Scholar] [ CrossRef] Ghoti, H.; Fibach, E.; Dana, M.; Abu Shaban, M.; Jeadi, H.; Braester, A.; Matas, Z.; Rachmilewitz, E. Oxidative stress contributes to hemolysis in patients with hereditary spherocytosis and can be ameliorated by fermented papaya preparation. Ann. Hematol. 2010, 90, 509–513. [ Google Scholar] [ CrossRef]Singh, S.P.; Kumar, S.; Mathan, S.V.; Tomar, M.S.; Singh, R.K.; Verma, P.K.; Kumar, A.; Kumar, S.; Singh, R.P.; Acharya, A. Therapeutic application of Carica papaya leaf extract in the management of human diseases. DARU J. Pharm. Sci. 2020, 28, 735–744. [ Google Scholar] [ CrossRef] [ PubMed] Amer, J.; Goldfarb, A.; Rachmilewitz, E.A.; Fibach, E. Fermented papaya preparation as redox regulator in blood cells ofβ-thalassemic mice and patients. Phytother. Res. 2008, 22, 820–828. [ Google Scholar] [ CrossRef] [ PubMed] Saeed, F.; Arshad, M.U.; Pasha, I.; Naz, R.; Batool, R.; Khan, A.A.; Nasir, M.A.; Shafique, B. Nutritional and Phyto-Therapeutic Potential of Papaya ( Carica papaya Linn.): An Overview. Int. J. Food Prop. 2014, 17, 1637–1653. [ Google Scholar] [ CrossRef]

Marotta, F.; Celep, G.S.; Cabeca, A.; Polimeni, A. Novel concepts on functional foods and nutrigenomics in healthy aging and chronic diseases: A review of fermented papaya preparation research progress. Funct. Foods Health Dis. 2012, 2, 120. [ Google Scholar] [ CrossRef] The papaya fruit extract is rich in antioxidants, including lycopene, which can help fight free radical damage and promote the healthy aging of your skin while minimizing damage. An animal study conducted in Italy found that when cancerous mice were immunized with papain, they exhibited an increased mean survival time compared to the non-immunized controls.Kong YR, et al. Beneficial role of Carica papaya extracts and phytochemicals on oxidative stress and related diseases: a mini review . Biology (Basel) . 2021. Papaya skin, pulp, and seeds contain a variety of phytochemicals, including carotenoids and polyphenols, [15] as well as benzyl isothiocyanates and benzyl glucosinates, with skin and pulp levels that increase during ripening. [16] The carotenoids, lutein and beta-carotene, are prominent in the yellow skin, while lycopene is dominant in the red flesh (table). [17] Studies show that the gel helps reduce pain and inflammation without the need for anesthesia or drilling during tooth removal. Papain is a special enzyme that’s found in raw papaya. It’s popular in folk medicine because of its ability to break down proteins, aid digestion and reduce inflammation. This is the easiest way to get the benefits of papaya. Organic papaya soap with fruit extract, vitamin C & E, and antioxidants can lighten your skin, reduce irregular pigmentation and improve collagen production. 7. Juice

a b Chia, C. L.; Manshardt, Richard M. (October 2001). "Why Some Papaya Plants Fail to Fruit" (PDF). Fruits and Nuts. College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa: 1–2 . Retrieved 1 April 2015. In transgenic papaya, resistance is produced by inserting the viral coat protein gene into the plant's genome. Doing so seems to cause a similar protective reaction in the plant to cross-protection, which involves using an attenuated virus to protect against a more dangerous strain. Conventional varieties of transgenic papaya has reduced resistance against heterologous (not closely related to the coat gene source) strains, forcing different localities to develop their own transgenic varieties. As of 2016, one transgenic line appears able to deal with three different heterologous strains in addition to its source. [35] [29] Papaya production – 2020 Papaya fruit extract can come in various products, including moisturizers, exfoliants, cleansers, and serums.Shen, Yan Hong; Yang, Fei Ying; Lu, Bing Guo; Zhao, Wan Wan; Jiang, Tao; Feng, Li; Chen, Xiao Jing; Ming, Ray (2019-01-16). "Exploring the differential mechanisms of carotenoid biosynthesis in the yellow peel and red flesh of papaya". BMC Genomics. 20 (1): 49. doi: 10.1186/s12864-018-5388-0. ISSN 1471-2164. PMC 6335806. PMID 30651061. Papaya fruit extract comes from unripened papayas. It is rich in essential vitamins, minerals, antioxidants, and enzymes beneficial for your body when eaten and for your skin, when applied topically. Papaya is a fantastic component to moisturize your skin. Adding honey to papaya offers better hydration, and keeps your skin supple and smooth. Both papaya and milk are good for exfoliation and make your skin clean and fresh. 2. For Oily Skin Sivinski, J.M.; Calkins, C.O.; Baranowski, R.; Harris, D.; Brambila, J.; Diaz, J.; Burns, R.E.; Holler, T.; Dodson, G. (April 1996). "Suppression of a Caribbean Fruit Fly (Anastrepha suspensa(Loew) Diptera: Tephritidae) Population through Augmented Releases of the ParasitoidDiachasmimorpha longicaudata(Ashmead) (Hymenoptera: Braconidae)". Biological Control. 6 (2): 177–185. doi: 10.1006/bcon.1996.0022. ISSN 1049-9644.

Papaya is also popular as a home remedy for melasma, a skin condition that causes dark, discolored patches. It is already clinically proven that papain in papaya can dissolve inactive protein and can lighten and soften the skin. Available Forms Of Papaya Papaya also helps to clean the pores and make the skin bright and clear. It also provides a fairer complexion by penetrating the inner layers of skin and thoroughly removing dirt and excess oil discharges. 4. Helps To Treat Skin Diseases Leave the mask on for 10–15 minutes, then rinse with warm water and pat your face dry with a towel. Follow up with your usual moisturizer. Being an excellent combination of antioxidants, vitamin C, and lycopene, papaya exhibits impressive results in reducing the depth of facial wrinkles. 3. Deeply Cleanses Skin

Ghoti, H.; Rosenbaum, H.; Fibach, E.; Rachmilewitz, E.A. Decreased hemolysis following administration of antioxidant—fermented papaya preparation (FPP) to a patient with PNH. Ann. Hematol. 2010, 89, 429–430. [ Google Scholar] [ CrossRef] A study published in the Journal of Clinical Pediatric Dentistry found that a papain-based gel called Papacarie was effective in removing infected tissues among patients with caries, or decaying teeth. How you choose to use papaya for maximizing benefits will depend on your unique skin type. Given below are a few ways to use papaya for your skin: 1. For Dry Skin Green papaya is used in Southeast Asian cooking, both raw and cooked. In some parts of Asia, the young leaves of the papaya are steamed and eaten like spinach. Many of these papaya face masks require just 5 ingredients or less, making them perfect for a last-minute spa day. If you don't have some of the ingredients on hand, you can leave them out or substitute with another ingredient you do have. And if you have any face mask left over, just put it in an airtight container in the refrigerator and use it within 2 to 3 days. 1. Papaya Facial Steam