The album consists of both covers of blues classics, as well as original tracks co-written by Lenny. In July 2009, Lenny Henry stated he was contractually obligated to perform and regretted his part in the show, [15] telling The Times in 2015 that his appearance on the show led to a profound "wormhole of depression", and he regretted his family not intervening.

On 6 November 2021, The Guardian published Black British culture matters, curated by Henry and Marcus Ryder for its Saturday Culture Issue No7. He was the voice of the "shrunken head" on the Knight Bus in the 2004 movie Harry Potter and the Prisoner of Azkaban, and read the audio book version of Neil Gaiman's Anansi Boys. On 16 March 2007, Henry made a cameo appearance as himself in a sketch with Catherine Tate, who appeared in the guise of her character Geordie Georgie from The Catherine Tate Show. K. Audio for a review copy of the unabridged audiobook edition, both via NetGalley, of ‘The Book of Legends: What if all the stories were real?On 31 December 2008 and 1 January 2009, he appeared on Jools Holland's Hootenanny on BBC Two, singing part of the song Mercy along with singer Duffy. Henry is associated with the British Comic Relief charity organisation, along with his former wife, comedienne Dawn French, and Griff Rhys Jones, and has hosted the show and also presented filmed reports from overseas on the work of the charity. The Boy With Wings: Attack of the Rampaging Robot, Macmillan Children's Books, 2023; ISBN 978-1035015924 96 pages.

Henry begins with his children’s show Tiswas and continues through his The Lenny Henry Show, which was broadcast for 20 years though not continuously. In 1994 The Daily Mail reported that Henry was set to star in a biographical film of Billy Strachan's life titled A Wing and a Prayer, however the script was never turned into a movie. I thought 'I'm going to do my O levels', which is a bizarre thing for a rock 'n' roll 21-year-old comedian to do". Around the same time, he co-hosted the children's programme Tiswas from 1978 until 1981 playing such characters as Rastafarian Algernon Razzmatazz, David Bellamy and Trevor McDoughnut (a parody of Trevor McDonald), and subsequently performed and wrote for the show Three of a Kind. They married on 20 October 1984 in Covent Garden, London [69] and have one child, an adopted daughter named Billie.It was a comedy thriller with John Shea about two DJs with a shared passion for Motown music being chased across Britain. Henry later released "hard-hitting animated blues video" directed by Iranian filmmaker, Sam Chegini titled The Cops Don't Know which was premiered by Classic Rock magazine on 20 April 2016. He introduced characters who both mocked and celebrated black British culture, such as Theophilus P.