Nakmareong, S., Kukongviriyapan, U., Pakdeechote, P., Donpunha, W., Kukongviriyapan, V., Kongyingyoes, B., Sompamit, K., and Phisalaphong, C. Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with L-NAME-induced hypertension. Naunyn Schmiedebergs Arch Pharmacol 2011;383(5):519-529. View abstract. The average daily intake in an Indian diet is much higher, between 60 and 100mg per kg of bodyweight. 19 Pregnancy: Turmeric is commonly used in small amounts as a spice in foods. But it's likely unsafe to use larger amounts of turmeric as a medicine during pregnancy. It might cause a menstrual period or stimulate the uterus, putting the pregnancy at risk. Do not take medicinal amounts of turmeric if you are pregnant. Turmeric might decrease how much talinolol the body absorbs. Taking turmeric while taking talinolol might decrease the effects of talinolol.

Turmeric might change how much paclitaxel stays in the body. Taking turmeric while taking paclitaxel might change the effects and side effects of paclitaxel. However, this doesn't seem to be a big concern. Madkor, H. R., Mansour, S. W., and Ramadan, G. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. Br J Nutr 2011;105(8):1210-1217. View abstract.

It’s thought that antioxidants, such as curcumin, can help with the symptoms of depression by managing the chronic inflammation that’s been highlighted by wider research. 18 Sharifi-Rad J, et al. (2020). Turmeric and its major compound curcumin on health: Bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications. Reyes-Gordillo, K., Segovia, J., Shibayama, M., Tsutsumi, V., Vergara, P., Moreno, M. G., and Muriel, P. Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. Fundam.Clin Pharmacol 2008;22(4):417-427. View abstract.

Fiala, M., Liu, P. T., Espinosa-Jeffrey, A., Rosenthal, M. J., Bernard, G., Ringman, J. M., Sayre, J., Zhang, L., Zaghi, J., Dejbakhsh, S., Chiang, B., Hui, J., Mahanian, M., Baghaee, A., Hong, P., and Cashman, J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc.Natl.Acad.Sci.U.S A 7-31-2007;104(31):12849-12854. View abstract. Huang, C. Y., Chen, J. H., Tsai, C. H., Kuo, W. W., Liu, J. Y., and Chang, Y. C. Regulation of extracellular signal-regulated protein kinase signaling in human osteosarcoma cells stimulated with nicotine. J Periodontal Res 2005;40(2):176-181. View abstract. Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., and Cole, G. M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 11-1-2001;21(21):8370-8377. View abstract. Dandekar, P. P., Jain, R., Patil, S., Dhumal, R., Tiwari, D., Sharma, S., Vanage, G., and Patravale, V. Curcumin-loaded hydrogel nanoparticles: application in anti-malarial therapy and toxicological evaluation. J Pharm Sci 2010;99(12):4992-5010. View abstract.

Satoskar, R. R., Shah, S. J., and Shenoy, S. G. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int.J Clin Pharmacol Ther.Toxicol. 1986;24(12):651-654. View abstract. Research into acid reflux and gastroesophageal reflux disease has shown these conditions may be caused by inflammation and oxidative stress and that they can be managed with antioxidants and supplements with soothing properties. 16

Rezvani, M. and Ross, G. A. Modification of radiation-induced acute oral mucositis in the rat. Int.J Radiat.Biol. 2004;80(2):177-182. View abstract. Leite, K. R., Chade, D. C., Sanudo, A., Sakiyama, B. Y., Batocchio, G., and Srougi, M. Effects of curcumin in an orthotopic murine bladder tumor model. Int.Braz.J Urol. 2009;35(5):599-606. View abstract.

How to Enjoy Turmeric

Peeyush, K. T., Gireesh, G., Jobin, M., and Paulose, C. S. Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats. Life Sci. 11-4-2009;85(19-20):704-710. View abstract. Korutla, L. and Kumar, R. Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochim.Biophys.Acta 12-30-1994;1224(3):597-600. View abstract. Buildup of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Taking turmeric extract by mouth reduces markers of liver injury in people who have this condition. It also seems to help prevent the build-up of more fat in the liver. Ashok, P. and Meenakshi, B. Contraceptive effect of Curcuma longa (L.) in male albino rat. Asian J Androl 2004;6(1):71-74. View abstract.

Curcumin may also be able to help support gut health, including managing excess gas, abdominal discomfort, and bloating. 12 A 2013 trial by the University of Nottingham found curcumin stimulates the gallbladder to produce bile, an essential substance needed to break down fat in foods. 13 Rao, C. V., Simi, B., and Reddy, B. S. Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis 1993;14(11):2219-2225. View abstract.

Turmeric might increase how much amlodipine the body absorbs. Taking turmeric while taking amlodipine might increase the effects and side effects of amlodipine.