Our study shows that VR, when integrated in a neurorehabilitation program, improves all clinical scale scores of gait and balance performance as well as a conventional balance program. Interestingly, only patients who performed VR improved in terms of smoothness of gait and ADLs, as demonstrated by the analysis of curvilinear walking tasks and by the increase of the ABC and CIQ scores. Celebi, B., Cemal-Gucu, A., Ok, M., Sakinan, S. & Akoglu, E. Hydrographic indications to understand the absence of Posidonia oceanica in the Levant Sea (Eastern Mediterranean). Biol. Mar. Mediterr. 13, 34–38 (2006). GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. Find out more at gsk.com/company. Cautionary statement regarding forward-looking statements relating to BELLUS Health Marion, A. F. Esquisse d’une topographie zoologique du Golfe de Marseille. Ann. Muséum Hist. Nat. Marseille 1, 6–108 (1883). Several quantitative parameters in the spatiotemporal, stability, and smoothness domains were obtained for the two walking tasks, as follows:

Gray, C.M., Maldonado, P.E., Wilson, M. & McNaughton, B. Tetrodes markedly improve the reliability and yield of multiple single-unit isolation from multi-unit recordings in cat striate cortex. J. Neurosci. Methods 63, 43–54 (1995). Gold, C., Henze, D.A., Koch, C. & Buzsáki, G. On the origin of the extracellular action potential waveform: A modeling study. J. Neurophysiol. 95, 3113–3128 (2006).Moreover, the MediSeH project can be considered the first effort to make an extensive collection of P. oceanica distribution data available online. Indeed, previous works 26 provided online access to seagrass spatial data at a broad resolution. As part of the MediSeH project, the collated current and historical data on the P. oceanica distribution were stored within a geodatabase and were made available through the development of an online GIS data viewer ( http://www.mareaproject.net/medviewer/), enabling their visualization. Logothetis, N.K., Kayser, C. & Oeltermann, A. In vivo measurement of cortical impedance spectrum in monkeys: implications for signal propagation. Neuron 55, 809–823 (2007).

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article. Conflict of interest Marba, N. et al. Diversity of European seagrass indicators: patterns within and across regions. Hydrobiologia 704, 265–278 (2013).Boudouresque, C. F. et al. A monitoring network based on the seagrass Posidonia oceanica in the North Western Mediterranean Sea. Biol. Mar. Mediterr. 7, 328–331 (2000). Fraschetti, S., Guarnieri, G., Bevilacqua, S., Terlizzi, A. & Boero, F. Protection enhances community and habitat stability: evidence from a Mediterranean Marine Protected Area. PLoS One 8, e81838 (2013). At a later stage, all the collated and standardized data were incorporated in a GIS database and they were made accessible on the MediSeH online GIS data viewer ( http://www.mareaproject.net/medviewer/). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note

RCC is a cough that persists for more than eight weeks despite optimal treatment of any underlying conditions or where there is no identifiable underlying cause. 6 Cough hypersensitivity syndrome – excessive coughing, often in response to relatively innocuous stimuli – is now identified as the primary pathology in RCC. RCC is a frequent, yet often under-recognised, medical condition with significant physical, social, and psychological consequences on a patient’s quality of life. Two-thirds of patients are women averaging between 50-60 years old. 7 There are currently no approved treatments for this condition in the US or the EU. About camlipixant Stability: Normalized Root Mean Square ( nRMS) of the acceleration measured at pelvis, trunk, and head levels. The values were obtained for the AP, ML, and CC signal components as well as the magnitude value. High nRMS values have been associated with higher levels of acceleration, and hence, decreased stability [ 42]; Traumatic brain injury (TBI) is considered a major cause of mortality and long-term physical, cognitive, and behavioural disability in young adults, especially in high-income countries [ 1, 2, 3, 4]. When the Glasgow Coma Scale (GCS) score (in the acute phase) is 8 or less [ 5], TBI is categorized as severe (sTBI). Lower quality of life is caused by disability following sTBI, which restricts daily activities and social interactions [ 6, 7, 8, 9, 10, 11]. Balance and gait issues are frequently evident in sTBI patients [ 12, 13], which increase their risk of falling and have a severe impact on their ability to perform activities of daily living (ADLs), their quality of life, and their ability to reintegrate into society [ 14, 15]. From a clinical point of view, locomotor evaluation allows a quantification of gait quality; wearable devices, such as the inertial measurement units (IMUs), permit the quantitative estimation of walking parameters such as walking speed, stride frequency, and stride length either in ecological environments (i.e., hospital, clinic) or in real-life scenarios [ 16].Both groups showed a significant improvement in BBS, DGI, CB&M, and DHI scores in the within-subjects comparison over time. Specifically, the results of the Wilcoxon signed-ranks test highlight a significant improvement in BBS and DHI in both groups at T1, T2, and T3. The VRg showed a significant improvement in all three assessment times in the CB&M as well, while the CRg showed an improvement only 8 weeks after the end of the training (T3). Furthermore, only the VRg showed a significant improvement in the ABC and CIQ scores over the assessment sessions. Additionally, a significant between-group difference was found in the ABC and CIQ score. After the standardization of maps and the creation of a shapefile representing the whole distribution of P. oceanica meadows, we estimated differences in seagrass extension by comparing current and historical maps we evaluated the extent of regression and calculated meadows’ variations caused by regressive phenomena. Where data and maps were available, regression values were calculated by ArcGIS ® software and listed in Table 2, reporting amounts of lost P. oceanica with relation to the coastline length for which current and historical information was available. McNaughton, B.L., O'Keefe, J. & Barnes, C.A. The stereotrode: a new technique for simultaneous isolation of several single units in the central nervous system from multiple unit records. J. Neurosci. Methods 8, 391–397 (1983). A loss of 30% of the meadows was reported along the Ligurian coasts since the 1960 s 20, whereas our estimate was 19%. In France, a P. oceanica regression of 23% was reported over the last 50 years, or, in more detail, 2% in Corsica (Cap Corse) in the last 15 years, 9.5% since the 1960’ (St. Florent), 4.3–5% in Marseille-Cortiou 49 and 90% along the coast of Marseille in the last 100 years 11. Our estimate for the French continental coast is equal to an average of 9%. In those cases where estimates differ, discrepancies are likely due to problems of accuracy of historical maps, which were identified by authors working in these areas 14, 20, 21.

GSK cautions investors that any forward-looking statements or projections made by GSK, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Such factors include, but are not limited to, those described in the Company's Annual Report on Form 20-F for 2022, GSK’s Q4 Results for 2022 and any impacts of the COVID-19 pandemic. References Chamberlain et al. The impact of chronic cough: a cross-sectional European survey. Lung. 2015 Jun;193(3):401-8. There is no change to GSK’s full-year 2023 guidance or the medium-term outlook for 2021-2026 of more than 5% sales and 10% adjusted operating profit CAGR* at CER**.Swindale, N.V. & Spacek, M.A. Spike sorting for polytrodes: a divide and conquer approach. Front. Syst. Neurosci. 8, 6 (2014).