MSM has shown to be able to relieve allergic rhinitis (hay fever), as well as inflammatory skin conditions like rosacea Joint degeneration can negatively impact your quality of life by limiting your movement and mobility. The group receiving the supplement also reported improved overall quality of life and less difficulty walking and getting out of bed ( 2). https://www.arthritis.org/health-wellness/treatment/complementary-therapies/supplements-and-vitamins/supplement-and-herb-guide-for-arthritis-symptoms Other reports show that up to three to six grams of MSM daily (divided into three doses normally) seems to be safe and well-tolerated.

Gel, lotion or cream versions can be applied to the skin to help treat conditions like skin irritation such as rosacea, allergic reactions, varicose veins and hemorrhoids. While it is popular as a natural arthritis treatment, MSM may not work for everyone. The Arthritis Foundation states that there are currently no large, well-controlled studies on MSM. The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophagesA study on 24 exercise-trained males found that those who took 3 g of MSM daily for 14 days had less pain and discomfort after exercise than those taking a placebo. I think it would be impossible to have a top MSM list without Kala Health on it. They are one of the premier brands of MSM on the market. A clinical trial testing the effects of MSM supplements on joint pain in 118 patients with osteoarthritis (such as with the knee) found that compared to a placebo, MSM supplements taken over 12 weeks resulted in more improvements in pain, swelling and joint mobility. MSM supplements were given in 500-milligram doses three times daily along with glucosamine (also taken in 500-milligram doses three times daily). So just what is MSM cream used for? A majority of published studies regarding this organic sulfur product are in relation to ingestion, but there has been frequent commentary regarding its use in conditions such as the following:

Hewlings, S., et al. (2018). Evaluating the impacts of methylsulfonylmethane on allergic rhinitis after a standard allergen challenge: Randomized double-blind exploratory study [Abstract]. Joksimovic N, Spasovski G, Joksimovic V, et al. Efficacy and tolerability of hyaluronic acid, tea tree oil and methyl-sulfonyl-methane in a new gel medical device for treatment of haemorrhoids in a double-blind, placebo-controlled clinical trial. Updates Surg 2012;64:195-201. View abstract. O'Dwyer PJ, et al. Use of polar solvents in chemoprevention of 1,2-dimethylhydrazine-induced colon cancer. Cancer 1988;62:944-8. View abstract.However, there is evidence that MSM in combination with other supplements may help a bit with the pain and swelling of knee osteoarthritis. Also, early animal research shows some promise for decreasing joint degeneration. One of the newest areas of research involving MSM is studying its effectiveness in fighting cancer cells. Although the research is limited, the results have been promising so far. You can get even more results using MSM on your skin when you combine it with other antioxidants, including vitamin C, vitamin E and vitamin A, which all help build new, healthy skin cells. 4. Lowers Muscle Pain/Spasms and Improves Exercise Recovery

Find out all about MSM including what it does, the benefits and risks, and how much you might need. Overview Klandorf H, et al. Dimethyl sulfoxide modulation of diabetes onset in NOD mice. Diabetes 1998;62:194-7. Decreases pain and inflammation associated with osteoarthritis , rheumatoid arthritis, bursitis and tendinitis Berardesca E, Cameli N, Cavallotti C, et al. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. J Cosmet Dermatol. 2008 Mar;7:8-14. View abstract.While organic MSM is found in fresh, raw foods, MSM – the compound used in supplements – is a highly concentrated white, crystalline powder and contains 34% sulphur. 3 What does MSM stand for? Tripathi R, Gupta S, Rai S, et al. Effect of topical application of methylsulfonylmethane (MSM), EDTA on pitting edema and oxidative stress in a double blind, placebo-controlled study. Cell Mol Biol (Noisy-le-grand). 2011 Feb 12;57:62-9. View abstract. Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing

Various studies suggest that taking MSM supplements could help with symptoms of arthritis or relieve joint pain. It also reduces the production of cytokines such as tumor necrosis factor alpha (TNF-ɑ) and interleukin 6 (IL-6), which are signaling proteins linked to systemic inflammation ( 5).Having said that, in the skincare world there is increasing anecdotal evidence that applying MSM can leave skin feeling softer and smoother.