Jaganathan, S.K.; Mandal, M. Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p53 in honey-induced apoptosis. Investig. New Drugs 2010, 28, 624–633. [ Google Scholar] [ CrossRef] [ PubMed] Hussein, S.Z.; Yusoff, K.M.; Makpol, S.; Yusof, Y.A.M. Antioxidant Capacities and Total Phenolic Contents Increase with Gamma Irradiation in Two Types of Malaysian Honey. Molecules 2011, 16, 6378–6395. [ Google Scholar] [ CrossRef] [ PubMed] A baked bone in ham with a sweet honey glaze is the perfect show-stopping main course for your next holiday gathering. It's easy to prep and feeds a lot of people at once with minimal prep. This recipe is light on the spices with just a touch of cinnamon, and some orange juice to balance out the honey and brown sugar. After scoring the ham and glazing it twice, you'll be sure to get that delicious caramelized crust that everyone loves! Spilioti, E.; Jaakkola, M.; Tolonen, T.; Lipponen, M.; Virtanen, V.; Chinou, I.; Kassi, E.; Karabournioti, S.; Moutsatsou, P. Phenolic Acid Composition, Antiatherogenic and Anticancer Potential of Honeys Derived from Various Regions in Greece. PLoS ONE 2014, 9, e94860. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version]

Oxidative stress has been hypothesized to be the contributing factors of many chronic diseases, including osteoporosis [ 6, 7]. Reactive oxygen species (ROS) directly promotes the formation of osteoclasts, the bone-resorbing cells, in a process mediated by receptor activation of nuclear factor-kappa-B (NF- κB) ligand (RANKL)-RANK interaction [ 8, 9]. This signalling pathway involves redox-sensitive components, such as tumour necrosis factor receptor-associated factor 6 (TRAF6), Rac1 (a member of the Rho-GTPase subfamily), and nicotinamide adenine dinucleotide phosphate oxidases (NOX) [ 10]. Oxidative stress also mediates the induction of mitochondrial dysfunction apoptosis [ 11, 12] and decreases the differentiation and activities of osteoblasts, the bone-forming cells [ 13]. Badeau, M.; Adlercreutz, H.; Kaihovaara, P.; Tikkanen, M.J. Estrogen A-ring structure and antioxidative effect on lipoproteins. J. Steroid Biochem. Mol. Biol. 2005, 96, 271–278. [ Google Scholar] [ CrossRef] [ PubMed] The phenolic and flavonoid contents of honey can correct the redox imbalance in the body by counteracting the deterioration caused by oxidants such as oxygen, hydroxide, superoxide, and/or lipid peroxyl radicals [ 31]. The synergistic effect of exogenous nonenzymatic antioxidants in honey can be observed when they provide support for endogenous antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), to eradicate ROS. One type of antioxidant may not be sufficient to ameliorate the damaging effect of oxidants. In contrast, it may be transformed into a pro-oxidant. In this regard, honey is advantageous by having several antioxidant constituents, which can assist each other to regenerate and prevent the formation of pro-oxidants [ 32, 33]. Additionally, both enzymatic and nonenzymatic antioxidant contents in honey may act at different cellular levels, by preventing oxidation of the macromolecules or stimulating gene expressions, which ultimately provoke an antioxidant response [ 31, 34]. Offsprings of rats fed with Tualang honey also had a higher GSH level and a lower lipid peroxidation level in their spinal cord tissue after being challenged with formalin-induced stress [ 35]. Apart from interacting with oxidants physically, polyphenols in honey can activate intracellular signalling cascades, such as phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), protein kinase B (PKB)/Akt, tyrosine kinases, protein kinase C (PKC), and mitogen-activated protein kinases (MAPKs) [ 36]. 3. Anti-Inflammatory Effects of Honey Jezierska-Drutel, A.; Rosenzweig, S.A.; Neumann, C.A. Role of oxidative stress and the microenvironment in breast cancer development and progression. Adv. Cancer Res. 2013, 119, 107–125. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] I prefer to use a bone-in ham, which has not been spiral-cut because it retains more of its juices when reheating in the oven. For this recipe, if you have a good meat thermometer, and a little patience, it will help you deliver a fantastic, juicy ham! Jump to:

Hecht, F.; Pessoa, C.F.; Gentile, L.B.; Rosenthal, D.; Carvalho, D.P.; Fortunato, R.S. The role of oxidative stress on breast cancer development and therapy. Tumour Biol. 2016, 37, 4281–4291. [ Google Scholar] [ CrossRef] [ PubMed] Several artists have covered “Honey Bones,” paying homage to its enchanting melodies and timeless lyrics. These covers often interpret the song in unique ways, adding new dimensions to its meaning. 10. How does “Honey Bones” fit into Dope Lemon’s discography? Kanzaki, H.; Shinohara, F.; Kanako, I.; Yamaguchi, Y.; Fukaya, S.; Miyamoto, Y.; Wada, S.; Nakamura, Y. Molecular regulatory mechanisms of osteoclastogenesis through cytoprotective enzymes. Redox Biol. 2016, 8, 186–191. [ Google Scholar] [ CrossRef][ Green Version] Fata, J.E.; Kong, Y.Y.; Li, J.; Sasaki, T.; Irie-Sasaki, J.; Moorehead, R.A.; Elliott, R.; Scully, S.; Voura, E.B.; Lacey, D.L.; et al. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell 2000, 103, 41–50. [ Google Scholar] [ CrossRef][ Green Version]

Kaur, R.P.; Rubal; Banipal, R.P.S.; Vashistha, R.; Dhiman, M.; Munshi, A. Association of elevated levels of C-reactive protein with breast cancer, breast cancer subtypes, and poor outcome. Curr. Probl. Cancer 2019, 43, 123–129. [ Google Scholar] [ CrossRef] [ PubMed] Ranganathan, S.; Halagowder, D.; Sivasithambaram, N.D. Quercetin Suppresses Twist to Induce Apoptosis in MCF-7 Breast Cancer Cells. PLoS ONE 2015, 10, e0141370. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] Ahmed, S.; Sulaiman, S.A.; Baig, A.A.; Ibrahim, M.; Liaqat, S.; Fatima, S.; Jabeen, S.; Shamim, N.; Othman, N.H. Honey as a Potential Natural Antioxidant Medicine: An Insight into Its Molecular Mechanisms of Action. Oxidative Med. Cell. Longev. 2018, 2018, e8367846. [ Google Scholar] [ CrossRef][ Green Version] Cauley, J.A. Estrogen and bone health in men and women. Steroids 2015, 99, 11–15. [ Google Scholar] [ CrossRef] [ PubMed]While the song may not have received mainstream awards, it has gained a dedicated following and critical acclaim for its lyrical prowess and emotional impact. 7. How does the song’s title relate to the lyrics? van’t Hof, R.J.; Ralston, S.H. Cytokine-induced nitric oxide inhibits bone resorption by inducing apoptosis of osteoclast progenitors and suppressing osteoclast activity. J. Bone Miner. Res. 1997, 12, 1797–1804. [ Google Scholar] [ CrossRef] Choi, J.A.; Kim, J.Y.; Lee, J.Y.; Kang, C.M.; Kwon, H.J.; Yoo, Y.D.; Kim, T.W.; Lee, Y.S.; Lee, S.J. Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. Int. J. Oncol. 2001, 19, 837–844. [ Google Scholar] [ CrossRef] [ PubMed] Zakaria, Z.; Zainal Abidin, Z.F.; Gan, S.H.; Wan Abdul Hamid, W.Z.; Mohamed, M. Effects of honey supplementation on safety profiles among postmenopausal breast cancer patients. J. Taibah Univ. Med. Sci. 2018, 13, 535–540. [ Google Scholar] [ CrossRef]

It also has a really nice taste, I like to call it “spicy honey”. So you won’t be having a hard time taking it. Biggest Downside: It’s not as powerful as the other 2 combinations. That’s why it didn’t relieve my pain, in my opinion. So I wouldn’t recommend it if you’ve had chronic joint pain for a while. The song evokes a range of emotions, including longing, desire, introspection, and a yearning for connection. Its simplicity and honesty resonate deeply with listeners. 6. Has “Honey Bones” received any awards or accolades? Chen, Y.; Zeng, C.; Zhan, Y.; Wang, H.; Jiang, X.; Li, W. Aberrant low expression of p85α in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b. Oncogene 2017, 36, 4692–4705. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version]Eteraf-Oskouei, T.; Najafi, M. Traditional and Modern Uses of Natural Honey in Human Diseases: A Review. Iran. J. Basic Med. Sci. 2013, 16, 731–742. [ Google Scholar] [ PubMed] In a study investigating the fracture healing properties of honey and hydroxyapatite in rats, a significantly better fracture healing was seen through better bone formation, union, and remodelling on the radiograph score in the rats with honey autograft as compared to the other treatment groups at the second week. The rats treated with honey alone showed the poorest healing based on the radiograph score throughout the treatment period. Histopathological investigations revealed that the group treated with hydroxyapatite alone showed the poorest results in bone marrow formation compared to all other treatment groups. Therefore, honey and hydroxyapatite together appeared to exert better healing effects on bone defects as compared to using them separately [ 86]. The antioxidant activity in honey is primarily attributed to the presence of phenolic compounds and flavonoids [ 26]. Phenolic compounds exert antioxidant activities via several different mechanisms, such as free radical scavenging, hydrogen donation, singlet oxygen quenching, and metal ion chelation [ 27]. The total phenolic content (TPC) of honey can be determined through the Folin–Ciocalteu method. Physically, a higher TPC is indicated by the colour of the honey, whereby honey with a darker appearance tends to have a higher TPC as compared to the lighter one [ 28, 29]. Other measures to determine the antioxidant potential of honey include 1,1-diphenyl-2-picrylhydrazyl scavenging assay, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) assay, oxygen radical absorbance capacity assay, and ferric reducing antioxidant power assay [ 30]. Moreira, A.J.; Ordoñez, R.; Cerski, C.T.; Picada, J.N.; García-Palomo, A.; Marroni, N.P.; Mauriz, J.L.; González-Gallego, J. Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. PLoS ONE 2015, 10, e0144517. [ Google Scholar] [ CrossRef] [ PubMed]