People with an active peptic ulcer or bleeding in the gut; those who've had two or more episodes of this in the past; and people who have ever experienced bleeding or perforation in the gut as a result of taking an NSAID.

Hazardous and harmful use. Nurofen Plus contains the opioid codeine and is a potential drug of abuse, misuse and addiction. Addiction can occur in patients appropriately prescribed Nurofen Plus at recommended doses. antiplatelet medicines to reduce the risk of blood clots or 'thin the blood', eg dipyridamole, clopidogrel, prasugrel, low-dose aspirin The adverse events observed most often are gastrointestinal in nature. Adverse events are mostly dose-dependent, in particular the risk of occurrence of gastrointestinal bleeding is dependent on the dosage range and duration of treatment.

Taking ibuprofen with other painkillers

Cardiac glycosides: NSAIDs may exacerbate cardiac failure, reduce GFR and increase plasma glycoside levels. aged between 12-18 years in whom respiratory function might be compromised, including post tonsillectomy and/or adenoidectomy for obstructive sleep apnoea (see Section 4.3 Contraindications; Section 4.4 Special Warnings and Precautions for Use, Paediatric use). This medicine is only available with a doctor's prescription. What Nurofen Plus contains Active ingredient If you or someone else receive too much (overdose), and experience one or more of the symptoms below, immediately and call triple zero (000) for an ambulance. Keep the person awake by talking to them or gently shaking them every now and then. You should follow the above steps even if someone other than you have accidentally used Nurofen Plus that was prescribed for you. If someone takes an overdose they may experience one or more of the following symptoms:

Caution (discussion with doctor or pharmacist) is required prior to starting treatment in patients with a history of hypertension and/or heart failure as fluid retention, hypertension and oedema have been reported in association with NSAID therapy.

Relieving period pain

Caution should be advised in patients receiving concomitant medications which could increase the risk of ulceration or bleeding, such as oral corticosteroids, anticoagulants such as warfarin, selective serotonin-reuptake inhibitors or anti-platelet agents such as aspirin (see section 4.5).

In serious poisoning metabolic acidosis may occur and the prothrombin time/INR may be prolonged, probably due to interference with the actions of circulating clotting factors. Acute renal failure and liver damage may occur. When GI bleeding or ulceration occurs in patients receiving Nurofen Plus, the treatment should be withdrawn. Period pain can impact your ability to carry out normal daily activities, including going to school or work. It’s usually worst when it starts (when the period starts or earlier), and tends to go away over the next 2 to 3 days. What causes period pain? Use of codeine containing products is contraindicated in women during breast feeding (see Section 4.6 Fertility, Pregnancy and Lactation, Use in lactation). Nurofen Plus contains the active ingredients Ibuprofen and Codeine phosphate. Ibuprofen belongs to a family of medicines called non-steroidal anti-inflammatory drugs (NSAIDS). These medicines work by relieving pain and/or inflammation (swelling, redness, soreness) and fever. Codeine is an opioid analgesic that works in the brain and spinal cord to relieve pain.During the third trimester of pregnancy, all prostaglandin synthesis inhibitors may expose the foetus to: After you have received medical advice for any side effects you experience, you can report side effects to the Therapeutic Goods Administration online at www.tga.gov.au/reporting-problems. By reporting side effects, you can help provide more information on the safety of this medicine. The white capsule-shaped tablets are marked 'N+' on one side and plain on the other. 4 Clinical Particulars Patients with a history of GI toxicity, particularly the elderly, patients with a history of gastrointestinal bleeding or perforation or peptic ulcer haemorrhage related to previous NSAID therapy should report any unusual abdominal symptoms (especially GI bleeding) particularly in the initial stages of treatment.