This way, the animal does not feel any pain and is not aware of the situation. To get the most out of the antler, the antler is usually cut very close to the base of the animal’s head. Once this is done, the supplement manufacturer needs to carefully remove the velvet from the antler itself. The content of organic matter in the antlers ranges from 36% to 52%. Calcium, phosphorus, magnesium, zinc and manganese are the most common minerals and their total content is fairly constant. Compared to other mammalian antlers, the deer antlers have a more balanced content of minerals, which increases their elasticity and resistance to fracture. Hence, dogs are not exposed to the risk of long and sharp splinters while chewing them. In vivo (Mice): The number of hippocampal neurons in the brain was restored and neuronal damage in the brain was reduced. CRH, ACTH, CORT, GR, MR↓ P. DiMarzio, R. Peila, O. Dowling, D.M. Timony, A. Balgobind, L.N. Lee, K.M. Kostroff, G.Y.F. Ho, Smoking and alcohol drinking effect on radiotherapy associated risk of second primary cancer and mortality among breast cancer patients. Cancer Epidemiol. 57, 97–103 (2018)

In vivo (Rats): Inhibition of tyrosine hydroxylase positive neuronal death. GAP-43, NF-H↑; Glu, GABA↓ Furthermore, keep in mind that IGF-1 is banned by many sports leagues and athletic associations. Thus, if you’re an athlete, using these supplements could be prohibited. For pet parents who aren’t comfortable with the prospect of antlers for dogs or for those who want other natural options, there are alternatives. Some potential choices include: Cow Hooves In vivo (Mice): Inhibits morphine-induced analgesic tolerance, somatic dependence, and postsynaptic DA receptor hypersensitivity.It contains high volumes of natural minerals and nutrients that aid circulation and improve metabolism. W.J. Song, Y.H. Li, J.G. Wang, Z.Y. Li, J.Q. Zhang, Characterization of nucleobases and nucleosides in the fruit of Alpinia oxyphylla collected from different cultivation regions. Drug Test Anal. 6, 239–245 (2014) Anti-fatigue and strengthening properties. Studies have tried giving mice antler velvet supplements. They found that the more nucleosides the supplements contain, the faster mice swam. This indicates improved strength and reduced fatigue ( 12, 23).

Z. Barzideh, A.A. Latiff, C.Y. Gan, M.Z. Abedin, A.K. Alias, ACE inhibitory and antioxidant activities of collagen hydrolysates from the ribbon jellyfish (Chrysaora sp.). Food Technol. Biotechnol. 52, 495–504 (2014) This is likely why young deer antler velvet supplements are revered by many traditional medicine practices. For example, they’ve been used in traditional Chinese medicine for thousands of years ( 2, 3, 5, 6). How the supplements are made Choosing the best antler treat for your dog will depend on your dog’s preferences and the type of durability you’re hoping to get out of the chew. Here are a few of our favorite antlers for dogs.

Healthy! Antlers are extremely nutritional and just a small supplement of powder per day can boost various aspects of a dog’s health. Antler powder can help with skin, joint, and digestive health as well as providing a shinier coat.

Antioxidants, on the other hand, are the kryptonite of free radicals. Antioxidants are not only able to reduce the damage caused by free radicals but also reduce the number of free radicals themselves. As you can imagine, this is very important when it comes to your health. In vivo (Rats): Inhibits nerve damage, oxidative stress and inflammation. IL-1β, IL-6, TNFα↓, Nrf-2, HO-1, p-IKKα, p-IKKβ, p-NF-κBp65, p-IκBα↑ The prepared samples of deer antlers were analyzed by nanoliter liquid phase (EASY-nLC 1000, Thermo Scientific, San Jose, CA, USA) coupled with high-resolution mass spectrometry (Orbitrap-Fusion, Thermo Scientific, San Jose, CA, USA). Desalting and enrichment were performed by a C18 column (100 μm × 3.5 cm, 5 μm, Thermo Scientific, San Jose, CA, USA), separation was by a C18 column (75 μm × 15 cm, 3 μm, Thermo Scientific, San Jose, CA, USA), flow rate was 300 nL/min, mobile phase A was 0.1% ( v/v) formic acid aqueous solution containing 2% acetonitrile, and mobile phase B was 0.1% ( v/v) formic acid aqueous solution containing 98% acetonitrile. Gradient elution was performed as follows (0~1 min, 1%B→6%B, 1~96 min, 6%B→22%B, 96~113 min, 22%B→30%B, 113~117 min, 30%B→95%B, 117~120 min, 95%B). The injection volume was 1 μL, content of 200 ng peptides.

What Are Deer Antler Supplements Exactly?

Ground antlers, in addition to being a source of phosphorus themselves, through their influence on the functioning of the digestive tract do not change the absorption of other minerals from the digestive content. Bone marrow mesenchymal stem cells: Activation of BMP-2/Smad1,5/Runx2 pathway; extracellular matrix mineralization, ALP↑ F.F. Wu, H.Q. Li, L.J. Jin, X.Y. Li, Y.S. Ma, J.S. You, S.Y. Li, Y.P. Xu, Deer antler base as a traditional Chinese medicine: a review of its traditional uses, chemistry and pharmacology. J. Ethnopharmacol. 145, 403–415 (2013) Elk antlers are probably the largest antlers compared to others out there. They are slightly darker in color than deer antlers, and contain more marrow content than the antlers of whitetail deer which makes them slightly softer. Elk antlers are also a good option as a split treat (more on that below). Moose Antlers for Dogs