Often the first signs are recognised too late and not treated in time. The consequences can be irreparable. The health of the gums and teeth can also have an impact on general wellbeing. The effect of PerioGard® on periodontitis has not been determined. An increase in supragingival calculus was noted in clinical testing with users of chlorhexidine gluconate oral rinse USP, 0.12% compared with control users. It is not known if chlorhexidine gluconate use results in an increase of subgingival calculus. Calculus deposits should be removed by a dental prophylaxis at intervals not greater than six months. Anaphylaxis, as well as serious allergic reactions, have been reported during postmarketing use with dental products containing chlorhexidine. SEE CONTRAINDICATIONS. PerioGard® is supplied as a blue liquid in a 16-fluid ounce (473 mL) (NDC 0126-0272-16) amber plastic bottle with child-resistant dosage cap. PerioGard® (Chlorhexidine Gluconate Oral Rinse USP, 0.12%) provides antimicrobial activity during oral rinsing. The clinical significance of chlorhexidine gluconate oral rinse’s antimicrobial activities is not clear. Microbiological sampling of plaque has shown a general reduction of counts of certain assayed bacteria, both aerobic and anaerobic, ranging from 54-97% through six months’ use.

COLGATE PerioGard Gum Protection Mouthwash 400ml | Gum Care COLGATE PerioGard Gum Protection Mouthwash 400ml | Gum Care

Reduces certain aerobic and anaerobic bacteria counts from 54-97% through six months’ clinical use2 The unique dual active formula has a lasting antibacterial effect**. The active ingredients are spread around the oral cavity instantly and start working immediately. It lastingly inhibits bacterial plaque build-up, effectively protecting from gum problems. Long-lasting antibacterial effect** PerioGard (Chlorhexidine Gluconate Oral Rinse USP, 0.12%) Alcohol Free oral rinse, [prescribing information, Rev.2019] Colgate Oral Pharmaceuticals , Inc.At Colgate we believe everyone deserves a future to smile about. Championing optimism means we are committed to creating a healthier planet and work every day to create healthy smiles for all. Studies conducted on human subjects and animals demonstrate chlorhexidine gluconate is poorly absorbed from the gastrointestinal tract. The mean plasma level of chlorhexidine gluconate reached a peak of 0.206 µg/g in humans 30 minutes after they ingested a 300-mg dose of the drug. Detectable levels of chlorhexidine gluconate were not present in the plasma of these subjects 12 hours after the compound was administered. Excretion of chlorhexidine gluconate occurred primarily through the feces (~90%). Less than 1% of the chlorhexidine gluconate ingested by these subjects was excreted in the urine. For patients having coexisting gingivitis and periodontitis, the presence or absence of gingival inflammation following treatment with PerioGard ® should not be used as a major indicator of underlying periodontitis. Help to protect your teeth and gums with Colgate PerioGard Gum Protection Toothpaste. This gum toothpaste has been designed to help fight the cause of gum problems, irritation* before they start. The gum toothpaste has a dual active formula with stannous and fluoride stabilised with zinc phosphate to provide a long-lasting antibacterial effect**. The formula in this gum toothpaste works effectively to help keep gums healthy and protect against the build up of plaque and cavities. Take care of your teeth and gums before problems and irritation start.

Toothbrushes - Colgate Toothbrushes - Colgate

PerioGard® product is a near-neutral solution (pH range 5-7). Chlorhexidine gluconate is a salt of chlorhexidine and gluconic acid. Its chemical structure is: At Colgate, we make toothpaste that promotes healthy smiles. Not only because having a healthy smile is important to your overall health, but because when you have a healthy smile, you actually smile more – and that’s a powerful thing. Smiles are the simplest form of optimism, something we need now more than ever. That’s why we’re committed to raising oral healthcare standards everywhere. PerioGard Gum Care Toothpaste BenefitsPregnancy: Teratogenic Effects: Reproduction studies have been performed in rats and rabbits at chlorhexidine gluconate doses up to 300 mg/kg/day and 40 mg/kg/day, respectively, and have not revealed evidence of harm to the fetus. However, adequate and well controlled studies in pregnant women have not been done. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Minor irritation and superficial desquamation of the oral mucosa have been noted in patients using chlorhexidine gluconate oral rinses. It takes access to care to make healthy smiles happen. Imagine if everyone had all the guidance they need to keep their smile healthy. We could eliminate so many preventable and treatable oral health problems. That’s our vision, and to reach it we’re raising oral health standards with our product solutions and creating healthy habit-building learning opportunities that are easy to do. Pharmacokinetic studies with a chlorhexidine gluconate oral rinse USP, 0.12% indicate approximately 30% of the active ingredient is retained in the oral cavity following rinsing. This retained drug is slowly released into the oral fluids.

Colgate PerioGard Chlorhexidine 0.12% Mouthwash Colgate PerioGard Chlorhexidine 0.12% Mouthwash

PerioGard Gum Protection mouthrinse helps to fight the cause of gum problems* and irritation, before it occurs. It doesn't just fight the symptoms.PerioGard ® can cause staining of oral surfaces, such as tooth surfaces, restorations, and the dorsum of the tongue. Not all patients will experience a visually significant increase in tooth staining. In clinical testing, 56% of the chlorhexidine gluconate oral rinse users exhibited a measurable increase in facial anterior stain, compared to 35% of control users after six months; 15% of the chlorhexidine gluconate users developed what was judged to be heavy stain, compared to 1% of control users after six months. Stain will be more pronounced in patients who have heavier accumulations of unremoved plaque. Stain resulting from the use of PerioGard ® does not adversely affect health of the gingivae or other oral tissues. Stain can be removed from most tooth surfaces by conventional professional prophylactic techniques. Additional time may be required to complete the prophylaxis. Discretion should be used when prescribing to patients with anterior facial restorations with rough surfaces or margins. If natural stain cannot be removed from these surfaces by a dental prophylaxis, patients should be excluded from PerioGard ® treatment if permanent discoloration is unacceptable. Stain in these areas may be difficult to remove by dental prophylaxis and, on rare occasions, may necessitate replacement of these restorations. Help protect your gums from problems and irritation with the Colgate PerioGard Gum Protection Mouthwash. This gum mouthwash has a formula that effectively keeps your gums and teeth healthy. Features Aqua, Xylitol, Hydrated Silica, Glycerin, Sodium Methyl Cocoyl Taurate, Tetrasodium Pyrophosphate, Aroma, Zinc Phosphate; Cellulose Gum, Sodium Citrate, Microcrystalline Cellulose, Cocamidopropyl Betaine, Stannous Fluoride, Sodium Saccharin, Sucralose, Limonene, CI 74160. Pediatric Use: Clinical effectiveness and safety of PerioGard® have not been established in children under the age of 18. Ingestion of 1 or 2 ounces of PerioGard ® (Chlorhexidine Gluconate Oral Rinse USP, 0.12%) by a small child (~10 kg body weight) might result in gastric distress, including nausea, or signs of alcohol intoxication. Medical attention should be sought if more than 4 ounces of PerioGard ® oral rinse is ingested by a small child or if signs of alcohol intoxication develop.