In this reality, the X-Men brought Deadpool to Dr. Benjamin Brighton (also known as Psycho-Man) in an attempt to cure him of his insanity. Unbeknownst to the X-Men however, Brighton had, in actuality, been brainwashing his patients to do his bidding as opposed to curing them. Brighton's treatment failed to brainwash Deadpool, instead destroying his inner voices, replacing them with a single voice that knew that the entire Universe was just a lie, and encouraging him to kill non-stop. Oh, Crap!: Hercules' reaction upon recognizing the island he and the other gods were summoned to in Again. Unfortunately, it's too late to save them from Medusa's head. In Again, Deadpool doesn't do anything to hurt Spider-Woman's infant son even after killing both her and Porcupine in the same room.

Again heavily plays with this in regards to the X-Men. Apart from the time-lost original five, all of them are killed offscreen. However, Deadpool notes that he's not the one who killed them. Rather, Wolverine did it already in a completely different comic (see Stealth Prequel below). In the alternate Earth ending of the Weapon X comic, Deadpool is recruited by Wolverine to be part of a new team of X-Men after the old team is killed. He joins, claiming Wolverine only wants him as the "token human". This version of Deadpool is killed by Agent Zero's Anti-Healing Factor corrosive acid. This version of Deadpool speaks in white text boxes. [122] X-Men '92In Superman/Batman Annual #1, an unnamed antimatter doppelganger of Deathstroke looks like Deadpool. [132] DC Rebirth has given Harley Quinn a stalker/friend named Wayne Wilkins AKA "Red Tool", who is a direct parody of Deadpool. [133] [134] In other media Television Gollan, Stuart (March 12, 2015). "Deadpool coming to X-Men: Battle of the Atom courtesy of Zen Studios". Stevivor . Retrieved March 23, 2023.

Deadpool is depicted as having a regenerative healing factor, which not only prevents him from being permanently injured through enhanced cell regeneration throughout his body, but also causes psychosis and mental instability, as his neurons are also affected by the accelerated regeneration. It is thought that while his psychosis is a handicap, it is also one of his assets as they make him an extremely unpredictable opponent. Taskmaster, who has photo-reflexive memory which allows him to copy anyone's fighting skills by observation, was unable to defeat Deadpool due to his chaotic and improvised fighting style. [70] Taskmaster has also stated that Deadpool is an expert at distracting his opponents. [70] [71] Wolverine #88; X-Force #47, 56; Deadpool #1-9, -1; Daredevil/Deadpool Annual '97; material from Wolverine Annual '95 Two incarnations of Deadpool, Normal and Lil, appear in a self-titled Pinball video game, voiced again by Nolan North and Brian Huskey respectively. [193] Deadpool Bi-Annual #1, Deadpool's Art of War #1–4, Deadpool's Secret Secret Wars #1–4, Mrs. Deadpool and the Howling Commandos #1–4

Ching, Albert (October 12, 2012). "Daniel Way Unleashes Red Hulk's Loud and Proud THUNDERBOLTS". Newsarama . Retrieved October 12, 2012.